TRPM7 is Overexpressed in Bladder Cancer and Promotes Proliferation, Migration, Invasion and Tumor Growth

Overview

Journal Oncol Rep

Specialty Oncology

Date 2017 Aug 10

PMID 28791418

Citations 28

Authors

Sheng-Lin Gao

Chui-ze Kong

Zhe Zhang

Ze-Liang Li

Jian-Bin Bi

Xian-Kui Liu

Affiliations

Soon will be listed here.

Abstract

Recent findings suggest that the melastatin transient receptor potential channel 7 (TRPM7) is overexpressed in many types of cancers and is involved in tumorigenesis. However, its expression pattern and the potential role in bladder cancer remain unclear. The aim of the present study was to investigate the expression status of TRPM7 and its relationship with the development of bladder cancer. In the present study, we observed that the expression of TRPM7 was significantly elevated in bladder cancer tissues compared with that noted in the adjacent non-tumor tissues. Furthermore, increased TRPM7 expression was significantly associated with recurrence, metastasis and prognosis. In addition, after knockdown of the expression of TRPM7 by siRNA, the proliferation and the motility of T24 and 5637 cells were obviously inhibited, and downregulation of TRPM7 was found to play an important role in bladder cancer cell apoptosis. In conclusion, our findings suggest that TRPM7 plays an important role in bladder cancer, and TRPM7 may serve as a potentially unfavorable factor and novel target for human bladder cancer.

Citing Articles

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The Role of TRPM7 in Oncogenesis.

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LncRNA DGUOK-AS1 facilitates non-small cell lung cancer growth and metastasis through increasing TRPM7 stability via m6A modification.

Feng Y, Wu F, Wu Y, Guo Z, Ji X Transl Oncol. 2023; 32:101661.

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On the modulation of TRPM channels: Current perspectives and anticancer therapeutic implications.

Ciaglia T, Vestuto V, Bertamino A, Gonzalez-Muniz R, Gomez-Monterrey I Front Oncol. 2023; 12:1065935.

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