Paths from DNA Damage and Signaling to Genome Rearrangements Via Homologous Recombination

Overview

Journal Mutat Res

Publisher Elsevier

Specialty Genetics

Date 2017 Aug 7

PMID 28779875

Citations 16

Authors

Jac A Nickoloff

Affiliations

Soon will be listed here.

Abstract

DNA damage is a constant threat to genome integrity. DNA repair and damage signaling networks play a central role maintaining genome stability, suppressing tumorigenesis, and determining tumor response to common cancer chemotherapeutic agents and radiotherapy. DNA double-strand breaks (DSBs) are critical lesions induced by ionizing radiation and when replication forks encounter damage. DSBs can result in mutations and large-scale genome rearrangements reflecting mis-repair by non-homologous end joining or homologous recombination. Ionizing radiation induces genetic change immediately, and it also triggers delayed events weeks or even years after exposure, long after the initial damage has been repaired or diluted through cell division. This review covers DNA damage signaling and repair pathways and cell fate following genotoxic insult, including immediate and delayed genome instability and cell survival/cell death pathways.

Citing Articles

Transgenic mice harboring direct repeat substrates reveal key underlying causes of homologous recombination in vivo.

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Human papillomavirus 16 E2 blocks cellular senescence in response to activation of the DNA damage response.

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Metnase and EEPD1: DNA Repair Functions and Potential Targets in Cancer Therapy.

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Involvement of HIF-1α in the Detection, Signaling, and Repair of DNA Double-Strand Breaks after Photon and Carbon-Ion Irradiation.

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