Risk Factors for Hepatitis B Transmission in South Brazil

Overview

Journal Mem Inst Oswaldo Cruz

Specialties Parasitology
Tropical Medicine

Date 2017 Aug 3

PMID 28767979

Citations 7

Authors

Vagner Reinaldo Zingalli Bueno Pereira

Jonas Michel Wolf

Camila Albani da Silva Luz

Glaucia Zuleide Stumm

Thais da Rocha Boeira

Josiane Galvan

Daniel Simon

Vagner Ricardo Lunge

Affiliations

Soon will be listed here.

Abstract

Background: Hepatitis B virus (HBV) infection is a major public health problem in Brazil. Several risk factors are involved in HBV infection and their identification by a rational and essential approach is required to prevent the transmission of this infection in Brazil.

Objectives: To evaluate risk factors associated with HBV infection in South Brazil.

Methods: A total of 260 patients with HBV and 260 controls from Caxias do Sul (state of Rio Grande do Sul, Brazil) participated in this study. All participants were given a standard questionnaire to yield the sociodemographic information and to identify HBV risk factors. HBV infection was detected by HBsAg test in all participants.

Findings: HBV infection in these cases was strongly associated with history of a family member HBV-infected, mainly mother [odds ratio (OR) = 4.86; 95% confidence intervals (CI): 1.69-13.91], father (OR = 5.28; 95% CI: 1.58-17.71), and/or siblings (OR = 22.16; 95% CI: 9.39-52.25); sharing personal objects (OR = 1.40; 95% CI: 1.37-2.38); and having history of blood transfusion (OR = 2.05; 95% CI: 1.10-2.84).

Conclusions: HBV infection was strongly associated with having a family member infected with hepatitis B, sharing personal objects, and having history of blood transfusion.

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References

Menegol D, Spilki F . Seroprevalence of Hepatitis B and C markers at the population level in the municipality of Caxias do Sul, southern Brazil. Braz J Microbiol. 2014; 44(4):1237-40. PMC: 3958193. DOI: 10.1590/S1517-83822014005000013. View

Parana R, Almeida D . HBV epidemiology in Latin America. J Clin Virol. 2006; 34 Suppl 1:S130-3. DOI: 10.1016/s1386-6532(05)80022-8. View

Roman S, Jose-Abrego A, Fierro N, Escobedo-Melendez G, Ojeda-Granados C, Martinez-Lopez E . Hepatitis B virus infection in Latin America: a genomic medicine approach. World J Gastroenterol. 2014; 20(23):7181-96. PMC: 4064063. DOI: 10.3748/wjg.v20.i23.7181. View

Ximenes R, Figueiredo G, Cardoso M, Stein A, Moreira R, Coral G . Population-Based Multicentric Survey of Hepatitis B Infection and Risk Factors in the North, South, and Southeast Regions of Brazil, 10-20 Years After the Beginning of Vaccination. Am J Trop Med Hyg. 2015; 93(6):1341-1348. PMC: 4674256. DOI: 10.4269/ajtmh.15-0216. View

Gusatti C, Costi C, Halon M, Grandi T, Medeiros A, Silva C . Hepatitis B Virus Genotype D Isolates Circulating in Chapecó, Southern Brazil, Originate from Italy. PLoS One. 2015; 10(8):e0135816. PMC: 4537142. DOI: 10.1371/journal.pone.0135816. View

Bertolini D, Gomes-Gouvea M, de Carvalho-Mello I, Saraceni C, Sitnik R, Grazziotin F . Hepatitis B virus genotypes from European origin explains the high endemicity found in some areas from southern Brazil. Infect Genet Evol. 2012; 12(6):1295-304. DOI: 10.1016/j.meegid.2012.04.009. View

Pereira L, Martelli C, Merchan-Hamann E, Montarroyos U, Braga M, de Lima M . Population-based multicentric survey of hepatitis B infection and risk factor differences among three regions in Brazil. Am J Trop Med Hyg. 2009; 81(2):240-7. View

Clemente C, Carrilho F, Pinho J, Ono-Nita S, Silva L, Moreira R . A phylogenetic study of hepatitis B virus in chronically infected Brazilian patients of Western and Asian descent. J Gastroenterol. 2009; 44(6):568-76. DOI: 10.1007/s00535-009-0044-8. View

de Oliveira C, Vilar E Silva A, Nunes Dos Santos K, Fecury A, de Almeida M, Fernandes A . Hepatitis B and C virus infection among Brazilian Amazon riparians. Rev Soc Bras Med Trop. 2011; 44(5):546-50. View

10.

Degenhardt L, Charlson F, Stanaway J, Larney S, Alexander L, Hickman M . Estimating the burden of disease attributable to injecting drug use as a risk factor for HIV, hepatitis C, and hepatitis B: findings from the Global Burden of Disease Study 2013. Lancet Infect Dis. 2016; 16(12):1385-1398. DOI: 10.1016/S1473-3099(16)30325-5. View

11.

Yang S, Wang D, Zhang Y, Yu C, Ren J, Xu K . Transmission of Hepatitis B and C Virus Infection Through Body Piercing: A Systematic Review and Meta-Analysis. Medicine (Baltimore). 2015; 94(47):e1893. PMC: 5058954. DOI: 10.1097/MD.0000000000001893. View

12.

Contini C, Badia L, Cultrera R, Grilli A, DE Togni A . Epidemiological, clinical and laboratory features of chronic hepatitis B infection in a cohort of immigrant and Italian patients from Ferrara, Italy. Ann Hepatol. 2012; 11(6):862-9. View

13.

Lobato C, Tavares-Neto J, Rios-Leite M, Trepo C, Vitvitski L, Parvaz P . Intrafamilial prevalence of hepatitis B virus in Western Brazilian Amazon region: epidemiologic and biomolecular study. J Gastroenterol Hepatol. 2006; 21(5):863-8. DOI: 10.1111/j.1440-1746.2006.04298.x. View

14.

Mota A, Guedes F, Areias J, Pinho L, Cardoso M . Epidemiological study of genotypes of hepatitis B virus in northern Portugal. J Med Virol. 2009; 81(7):1170-6. DOI: 10.1002/jmv.21526. View

15.

Niederau C . Chronic hepatitis B in 2014: great therapeutic progress, large diagnostic deficit. World J Gastroenterol. 2014; 20(33):11595-617. PMC: 4155353. DOI: 10.3748/wjg.v20.i33.11595. View

16.

Matos M, Ferreira R, Rodrigues F, Marinho T, Lopes C, Novais A . Occult hepatitis B virus infection among injecting drug users in the Central-West Region of Brazil. Mem Inst Oswaldo Cruz. 2013; 108(3). PMC: 4005573. DOI: 10.1590/S0074-02762013000300019. View

17.

Barlean L, Saveanu I, Balcos C . Dental patients' attitudes towards infection control. Rev Med Chir Soc Med Nat Iasi. 2014; 118(2):524-7. View

18.

Jafari S, Buxton J, Afshar K, Copes R, Baharlou S . Tattooing and risk of hepatitis B: a systematic review and meta-analysis. Can J Public Health. 2012; 103(3):207-12. PMC: 6974244. View

19.

Deterding K, Heidelberger S, Wiebner B, Meining K, Cornberg M, Manns M . [Knowledge and management of hepatitis B virus infected patients in Germany]. Dtsch Med Wochenschr. 2012; 137(15):774-80. DOI: 10.1055/s-0032-1304852. View

20.

Pas S, Fries E, de Man R, Osterhaus A, Niesters H . Development of a quantitative real-time detection assay for hepatitis B virus DNA and comparison with two commercial assays. J Clin Microbiol. 2000; 38(8):2897-901. PMC: 87141. DOI: 10.1128/JCM.38.8.2897-2901.2000. View