The Involvement of Mg in Regulation of Cellular and Mitochondrial Functions

Overview

Journal Oxid Med Cell Longev

Publisher Wiley

Specialties Cell Biology
Endocrinology

Date 2017 Aug 1

PMID 28757913

Citations 69

Authors

Ivana Pilchova

Katarina Klacanova

Zuzana Tatarkova

Peter Kaplan

Peter Racay

Affiliations

Soon will be listed here.

Abstract

Mg is an essential mineral with pleotropic impacts on cellular physiology and functions. It acts as a cofactor of several important enzymes, as a regulator of ion channels such as voltage-dependent Ca channels and K channels and on Ca-binding proteins. In general, Mg is considered as the main intracellular antagonist of Ca, which is an essential secondary messenger initiating or regulating a great number of cellular functions. This review examines the effects of Mg on mitochondrial functions with a particular focus on energy metabolism, mitochondrial Ca handling, and apoptosis.

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