Mechanisms of Protein Homeostasis (proteostasis) Maintain Stem Cell Identity in Mammalian Pluripotent Stem Cells

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2017 Jul 28

PMID 28748323

Citations 26

Authors

Alireza Noormohammadi

Giuseppe Calculli

Ricardo Gutierrez-Garcia

Amirabbas Khodakarami

Seda Koyuncu

David Vilchez

Affiliations

Soon will be listed here.

Abstract

Protein homeostasis, or proteostasis, is essential for cell function, development, and organismal viability. The composition of the proteome is adjusted to the specific requirements of a particular cell type and status. Moreover, multiple metabolic and environmental conditions challenge the integrity of the proteome. To maintain the quality of the proteome, the proteostasis network monitors proteins from their synthesis through their degradation. Whereas somatic stem cells lose their ability to maintain proteostasis with age, immortal pluripotent stem cells exhibit a stringent proteostasis network associated with their biological function and intrinsic characteristics. Moreover, growing evidence indicates that enhanced proteostasis mechanisms play a central role in immortality and cell fate decisions of pluripotent stem cells. Here, we will review new insights into the melding fields of proteostasis and pluripotency and their implications for the understanding of organismal development and survival.

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