Amyotrophic Lateral Sclerosis Mechanism: Insights from the Models

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2024 Jan 11

PMID 38201303

Authors

Lili Chen

Shumei Zhang

Sai Liu

Shangbang Gao

Affiliations

Soon will be listed here.

Abstract

Amyotrophic Lateral Sclerosis (ALS) is a debilitating neurodegenerative condition characterized by the progressive degeneration of motor neurons. Despite extensive research in various model animals, the cellular signal mechanisms of ALS remain elusive, impeding the development of efficacious treatments. Among these models, a well-characterized and diminutive organism, (), has emerged as a potent tool for investigating the molecular and cellular dimensions of ALS pathogenesis. This review summarizes the contributions of models to our comprehension of ALS, emphasizing pivotal findings pertaining to genetics, protein aggregation, cellular pathways, and potential therapeutic strategies. We analyze both the merits and constraints of the system in the realm of ALS research and point towards future investigations that could bridge the chasm between foundational discoveries and clinical applications.

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