LncRNAs in Development and Disease: from Functions to Mechanisms

Overview

Journal Open Biol

Specialties Biology
Cell Biology
Molecular Biology

Date 2017 Jul 28

PMID 28747406

Citations 75

Authors

M Joaquina Delas

Gregory J Hannon

Affiliations

Soon will be listed here.

Abstract

Differential expression of long non-coding RNAs (lncRNAs) during differentiation and their misregulation in cancer highlight their potential as cell fate regulators. While some example lncRNAs have been characterized in great detail, the functional relevance of others has been called into question. Finding functional lncRNAs will most probably require a combination of complementary approaches that will greatly vary depending on their mode of action. In this review, we discuss the different tools available to dissect genetically lncRNA requirements and how each is best suited to studies in particular contexts. Moreover, we review different strategies used to select candidate lncRNAs and give an overview of lncRNAs described to regulate development and cancer through different mechanisms.

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