Human Zika Infection Induces a Reduction of IFN-γ Producing CD4 T-cells and a Parallel Expansion of Effector Vδ2 T-cells

Overview

Journal Sci Rep

Specialty Science

Date 2017 Jul 26

PMID 28740159

Citations 24

Authors

Eleonora Cimini

Concetta Castilletti

Alessandra Sacchi

Rita Casetti

Veronica Bordoni

Antonella Romanelli

Federica Turchi

Federico Martini

Nicola Tumino

Emanuele Nicastri

Angela Corpolongo

Antonino Di Caro

Gary Kobinger

Alimuddin Zumla

Maria Rosaria Capobianchi

Giuseppe Ippolito

Chiara Agrati

Affiliations

Soon will be listed here.

Abstract

The definition of the immunological response to Zika (ZIKV) infection in humans represents a key issue to identify protective profile useful for vaccine development and for pathogenesis studies. No data are available on the cellular immune response in the acute phase of human ZIKV infection, and its role in the protection and/or pathogenesis needs to be clarified. We studied and compared the phenotype and functionality of T-cells in patients with acute ZIKV and Dengue viral (DENV) infections. A significant activation of T-cells was observed during both ZIKV and DENV infections. ZIKV infection was characterized by a CD4 T cell differentiation toward effector cells and by a lower frequency of IFN-γ producing CD4 T cells. Moreover, a substantial expansion of CD3CD4CD8 T-cell subset expressing Vδ2 TCR was specifically observed in ZIKV patients. Vδ2 T cells presented a terminally differentiated profile, expressed granzyme B and maintained their ability to produce IFN-γ. These findings provide new knowledge on the immune response profile during self-limited infection that may help in vaccine efficacy definition, and in identifying possible immuno-pathogenetic mechanisms of severe infection.

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