Advances in Imaging Instrumentation for Nuclear Cardiology

Overview

Journal J Nucl Cardiol

Specialty Cardiology & Vascular Diseases

Date 2017 Jul 19

PMID 28718074

Citations 9

Authors

Jae Sung Lee

Gil Kovalski

Tali Sharir

Dong Soo Lee

Affiliations

Soon will be listed here.

Abstract

Advances in imaging instrumentation and technology have greatly contributed to nuclear cardiology. Dedicated cardiac SPECT cameras incorporating novel, highly efficient detector, collimator, and system designs have emerged with the expansion of nuclear cardiology. Solid-state radiation detectors incorporating cadmium zinc telluride, which directly convert radiation to electrical signals and yield improved energy resolution and spatial resolution and enhanced count sensitivity geometries, are increasingly gaining favor as the detector of choice for application in dedicated cardiac SPECT systems. Additionally, hybrid imaging systems in which SPECT and PET are combined with X-ray CT are currently widely used, with PET/MRI hybrid systems having also been recently introduced. The improved quantitative SPECT/CT has the potential to measure the absolute quantification of myocardial blood flow and flow reserve. Rapid development of silicon photomultipliers leads to enhancement in PET image quality and count rates. In addition, the reduction of emission-transmission mismatch artifacts via application of accurate time-of-flight information, and cardiac motion de-blurring aided by anatomical images, are emerging techniques for further improvement of cardiac PET. This article reviews recent advances such as these in nuclear cardiology imaging instrumentation and technology, and the corresponding diagnostic benefits.

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References

Shimizu Y, Kuge Y . Recent Advances in the Development of PET/SPECT Probes for Atherosclerosis Imaging. Nucl Med Mol Imaging. 2016; 50(4):284-291. PMC: 5135693. DOI: 10.1007/s13139-016-0418-9. View

Einstein A, Blankstein R, Andrews H, Fish M, Padgett R, Hayes S . Comparison of image quality, myocardial perfusion, and left ventricular function between standard imaging and single-injection ultra-low-dose imaging using a high-efficiency SPECT camera: the MILLISIEVERT study. J Nucl Med. 2014; 55(9):1430-7. PMC: 4486330. DOI: 10.2967/jnumed.114.138222. View

Lee J, Kim J . Recent advances in hybrid molecular imaging systems. Semin Musculoskelet Radiol. 2014; 18(2):103-22. DOI: 10.1055/s-0034-1371014. View

Knoll P, Kotalova D, Kochle G, Kuzelka I, Minear G, Mirzaei S . Comparison of advanced iterative reconstruction methods for SPECT/CT. Z Med Phys. 2011; 22(1):58-69. DOI: 10.1016/j.zemedi.2011.04.007. View

Laitinen I, Saraste A, Weidl E, Poethko T, Weber A, Nekolla S . Evaluation of alphavbeta3 integrin-targeted positron emission tomography tracer 18F-galacto-RGD for imaging of vascular inflammation in atherosclerotic mice. Circ Cardiovasc Imaging. 2009; 2(4):331-8. DOI: 10.1161/CIRCIMAGING.108.846865. View

Danad I, Raijmakers P, Harms H, Heymans M, van Royen N, Lubberink M . Impact of anatomical and functional severity of coronary atherosclerotic plaques on the transmural perfusion gradient: a [15O]H2O PET study. Eur Heart J. 2014; 35(31):2094-105. DOI: 10.1093/eurheartj/ehu170. View

Wehner J, Weissler B, Dueppenbecker P, Gebhardt P, Goldschmidt B, Schug D . MR-compatibility assessment of the first preclinical PET-MRI insert equipped with digital silicon photomultipliers. Phys Med Biol. 2015; 60(6):2231-55. DOI: 10.1088/0031-9155/60/6/2231. View

Zaidi H, Ojha N, Morich M, Griesmer J, Hu Z, Maniawski P . Design and performance evaluation of a whole-body Ingenuity TF PET-MRI system. Phys Med Biol. 2011; 56(10):3091-106. PMC: 4059360. DOI: 10.1088/0031-9155/56/10/013. View

Boellaard R, Quick H . Current image acquisition options in PET/MR. Semin Nucl Med. 2015; 45(3):192-200. DOI: 10.1053/j.semnuclmed.2014.12.001. View

10.

Ben-Haim S, Murthy V, Breault C, Allie R, Sitek A, Roth N . Quantification of Myocardial Perfusion Reserve Using Dynamic SPECT Imaging in Humans: A Feasibility Study. J Nucl Med. 2013; 54(6):873-9. PMC: 3951831. DOI: 10.2967/jnumed.112.109652. View

11.

Chang S, Nabi F, Xu J, Peterson L, Achari A, Pratt C . The coronary artery calcium score and stress myocardial perfusion imaging provide independent and complementary prediction of cardiac risk. J Am Coll Cardiol. 2009; 54(20):1872-82. DOI: 10.1016/j.jacc.2009.05.071. View

12.

Berman D, Maddahi J, Tamarappoo B, Czernin J, Taillefer R, Udelson J . Phase II safety and clinical comparison with single-photon emission computed tomography myocardial perfusion imaging for detection of coronary artery disease: flurpiridaz F 18 positron emission tomography. J Am Coll Cardiol. 2012; 61(4):469-477. PMC: 4316725. DOI: 10.1016/j.jacc.2012.11.022. View

13.

Rubeaux M, Joshi N, Dweck M, Fletcher A, Motwani M, Thomson L . Motion Correction of 18F-NaF PET for Imaging Coronary Atherosclerotic Plaques. J Nucl Med. 2015; 57(1):54-9. DOI: 10.2967/jnumed.115.162990. View

14.

Garcia E . Are SPECT measurements of myocardial blood flow and flow reserve ready for clinical use?. Eur J Nucl Med Mol Imaging. 2014; 41(12):2291-3. PMC: 4229445. DOI: 10.1007/s00259-014-2924-2. View

15.

Esteves F, Raggi P, Folks R, Keidar Z, Askew J, Rispler S . Novel solid-state-detector dedicated cardiac camera for fast myocardial perfusion imaging: multicenter comparison with standard dual detector cameras. J Nucl Cardiol. 2009; 16(6):927-34. PMC: 2776146. DOI: 10.1007/s12350-009-9137-2. View

16.

Slomka P, Pan T, Berman D, Germano G . Advances in SPECT and PET Hardware. Prog Cardiovasc Dis. 2015; 57(6):566-78. DOI: 10.1016/j.pcad.2015.02.002. View

17.

Kwon S, Lee J, Yoon H, Ito M, Ko G, Choi J . Development of small-animal PET prototype using silicon photomultiplier (SiPM): initial results of phantom and animal imaging studies. J Nucl Med. 2011; 52(4):572-9. DOI: 10.2967/jnumed.110.079707. View

18.

Nguyen N, Vercher-Conejero J, Sattar A, Miller M, Maniawski P, Jordan D . Image Quality and Diagnostic Performance of a Digital PET Prototype in Patients with Oncologic Diseases: Initial Experience and Comparison with Analog PET. J Nucl Med. 2015; 56(9):1378-85. DOI: 10.2967/jnumed.114.148338. View

19.

Shiraishi S, Sakamoto F, Tsuda N, Yoshida M, Tomiguchi S, Utsunomiya D . Prediction of left main or 3-vessel disease using myocardial perfusion reserve on dynamic thallium-201 single-photon emission computed tomography with a semiconductor gamma camera. Circ J. 2015; 79(3):623-31. DOI: 10.1253/circj.CJ-14-0932. View

20.

Duvall W, Slomka P, Gerlach J, Sweeny J, Baber U, Croft L . High-efficiency SPECT MPI: comparison of automated quantification, visual interpretation, and coronary angiography. J Nucl Cardiol. 2013; 20(5):763-73. PMC: 3820488. DOI: 10.1007/s12350-013-9735-x. View