Quick or Quality? How MRNA Escapes Nuclear Quality Control During Stress

Overview

Journal RNA Biol

Specialty Molecular Biology

Date 2017 Jul 15

PMID 28708448

Citations 18

Authors

Gesa Zander

Heike Krebber

Affiliations

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Abstract

Understanding the mechanisms for mRNA production under normal conditions and in response to cytotoxic stresses has been subject of numerous studies for several decades. The shutdown of canonical mRNA transcription, export and translation is required to have enough free resources for the immediate production of heat shock proteins that act as chaperones to sustain cellular processes. In recent work we uncovered a simple mechanism, in which the export block of regular mRNAs and a fast export of heat shock mRNAs is achieved by deactivation of the nuclear mRNA quality control mediated by the guard proteins. In this point of view we combine long known data with recently gathered information that support this novel model, in which cells omit quality control of stress responsive transcripts to ensure survival.

Citing Articles

Defenders of the Transcriptome: Guard Protein-Mediated mRNA Quality Control in .

Querl L, Krebber H Int J Mol Sci. 2024; 25(19).

PMID: 39408571 PMC: 11476243. DOI: 10.3390/ijms251910241.

dsRNA formation leads to preferential nuclear export and gene expression.

Coban I, Lamping J, Hirsch A, Wasilewski S, Shomroni O, Giesbrecht O Nature. 2024; 631(8020):432-438.

PMID: 38898279 PMC: 11236707. DOI: 10.1038/s41586-024-07576-w.

Characterization of a nuclear transport factor 2-like domain-containing protein in Plasmodium berghei.

Niikura M, Fukutomi T, Mitobe J, Kobayashi F Malar J. 2024; 23(1):13.

PMID: 38195464 PMC: 10777651. DOI: 10.1186/s12936-024-04839-9.

Surveillance of 3' mRNA cleavage during transcription termination requires CF IB/Hrp1.

Li J, Querl L, Coban I, Salinas G, Krebber H Nucleic Acids Res. 2023; 51(16):8758-8773.

PMID: 37351636 PMC: 10484732. DOI: 10.1093/nar/gkad530.

A guard protein mediated quality control mechanism monitors 5'-capping of pre-mRNAs.

Klama S, Hirsch A, Schneider U, Zander G, Seel A, Krebber H Nucleic Acids Res. 2022; 50(19):11301-11314.

PMID: 36305816 PMC: 9638935. DOI: 10.1093/nar/gkac952.

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