The Plasticity of Th17 Cells in the Pathogenesis of Rheumatoid Arthritis

Overview

Journal J Clin Med

Specialty General Medicine

Date 2017 Jul 13

PMID 28698517

Citations 42

Authors

Shigeru Kotake

Toru Yago

Tsuyoshi Kobashigawa

Yuki Nanke

Affiliations

Soon will be listed here.

Abstract

Helper T (Th) cells play an important role in the pathogenesis of autoimmune diseases, including rheumatoid arthritis (RA). It has been revealed that Th17 cells can shift to Th1 cells (i.e., "nonclassic Th1 cells"), which are reported to be more pathogenic than Th17 cells per se Thus, the association of Th cells in the pathogenesis of autoimmune disease has become more complicated. We recently reported using peripheral blood from untreated and early-onset RA patients that the ratio of CD161+Th1 cells (i.e., Th17-derived Th1 cells to CD161+Th17 cells) is elevated and that levels of interferon-γ (IFNγ)+Th17 cells are inversely correlated with levels of anti-CCP antibodies. Here, we review the plasticity of Th17 cells in the pathogenesis of RA, suggesting possible implications for novel therapies.

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