Are People with an Orofacial Cleft at a Higher Risk of Dental Caries? A Systematic Review and Meta-analysis

Overview

Journal Br Dent J

Specialty Dentistry

Date 2017 Jul 8

PMID 28684841

Citations 18

Authors

V Worth

R Perry

T Ireland

A K Wills

J Sandy

A Ness

Affiliations

Soon will be listed here.

Abstract

Objective To establish whether children born with an orofacial cleft have a higher risk of dental caries than individuals without cleft.Design A systematic review and meta-analysisMethods The search strategy was based on the key words 'cleft lip palate' and 'oral hygiene caries decay'. Ten databases were searched from their inception to April 2016 to identify all relevant studies. All data were extracted by two independent reviewers. The primary outcome measure was caries measured by the decayed, missing, filled surfaces/teeth index (dmfs/dmft or DMFS/DMFT).Results Twenty-four studies met the selection criteria. All of the studies were observational. Twenty-two studies were suitable for inclusion in the meta-analysis. The overall pooled mean difference in dmft was 0.63 (95% CI: 0.47 to 0.79) and in DMFT was 0.28 (95% CI: 0.22 to 0.34).Conclusion Individuals with cleft lip and/or palate have higher caries prevalence, both in the deciduous and the permanent dentitions.

Citing Articles

An Evaluation of Dental Caries Status in Children with Oral Clefts: A Cross-Sectional Study.

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Oral health in patients with cleft lip and palate: a systematic literature review and meta-analysis of periodontal and dental disease and oral microbiota (part 1).

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Are parental sociodemographic factors, oral health knowledge and practices linked to the oral health habits of their children with cleft lip and palate?.

Altun D, Karahan S, Ozgur F, Uzamis Tekcicek M, Turgut M Acta Odontol Scand. 2024; 83:404-411.

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Characterization of the oral microbiota and the relationship of the oral microbiota with the dental and periodontal status in children and adolescents with nonsyndromic cleft lip and palate. Systematic literature review and meta-analysis.

Escobar-Arregoces F, Eras M, Bustos A, Suarez-Castillo A, Garcia-Robayo D, Del Pilar Bernal M Clin Oral Investig. 2024; 28(5):245.

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Self-perceived oral health and orofacial aesthetics of cleft patients.

van der Knaap-Kind L, Schipper L, Bonifacio C, Wolvius E, Kragt L Eur Arch Paediatr Dent. 2024; 25(3):359-366.

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References

Britton K, Welbury R . Dental caries prevalence in children with cleft lip/palate aged between 6 months and 6 years in the West of Scotland. Eur Arch Paediatr Dent. 2010; 11(5):236-41. DOI: 10.1007/BF03262754. View

Parapanisiou V, Gizani S, Makou M, Papagiannoulis L . Oral health status and behaviour of Greek patients with cleft lip and palate. Eur Arch Paediatr Dent. 2009; 10(2):85-9. DOI: 10.1007/BF03321606. View

Al-Wahadni A, Abu Alhaija E, Al-Omari M . Oral disease status of a sample of Jordanian people ages 10 to 28 with cleft lip and palate. Cleft Palate Craniofac J. 2005; 42(3):304-8. DOI: 10.1597/03-161.1. View

Ankola A, Nagesh L, Hegde P, Karibasappa G . Primary dentition status and treatment needs of children with cleft lip and/or palate. J Indian Soc Pedod Prev Dent. 2005; 23(2):80-2. DOI: 10.4103/0970-4388.16447. View

Ditmyer M, Dounis G, Mobley C, Schwarz E . A case-control study of determinants for high and low dental caries prevalence in Nevada youth. BMC Oral Health. 2010; 10:24. PMC: 2989299. DOI: 10.1186/1472-6831-10-24. View

Hewson A, McNamara C, FOLEY T, Sandy J . Dental experience of cleft affected children in the west of Ireland. Int Dent J. 2001; 51(2):73-6. DOI: 10.1002/j.1875-595x.2001.tb00825.x. View

Lehtonen V, K Sandor G, Ylikontiola L, Koskinen S, Pesonen P, Harila V . Dental treatment need and dental general anesthetics among preschool-age children with cleft lip and palate in northern Finland. Eur J Oral Sci. 2015; 123(4):254-9. DOI: 10.1111/eos.12195. View

Iheozor-Ejiofor Z, Worthington H, Walsh T, OMalley L, Clarkson J, Macey R . Water fluoridation for the prevention of dental caries. Cochrane Database Syst Rev. 2015; (6):CD010856. PMC: 6953324. DOI: 10.1002/14651858.CD010856.pub2. View

Freitas A, de Barros L, Fiorini J, Boriollo M, Moreira A, Magalhaes C . Caries experience in a sample of adolescents and young adults with cleft lip and palate in Brazil. Cleft Palate Craniofac J. 2012; 50(2):187-91. DOI: 10.1597/11-143. View

10.

Jindal A, McMeans M, Narayanan S, Rose E, Jain S, Marazita M . Women are more susceptible to caries but individuals born with clefts are not. Int J Dent. 2011; 2011:454532. PMC: 3124302. DOI: 10.1155/2011/454532. View

11.

Zhu W, Xiao J, Liu Y, Wu J, Li J . Caries experience in individuals with cleft lip and/or palate in China. Cleft Palate Craniofac J. 2010; 47(1):43-7. DOI: 10.1597/07-076.1. View

12.

Antonarakis G, Palaska P, Herzog G . Caries prevalence in non-syndromic patients with cleft lip and/or palate: a meta-analysis. Caries Res. 2013; 47(5):406-13. DOI: 10.1159/000349911. View

13.

Bian Z, Du M, Bedi R, Holt R, Jin H, Fan M . Caries experience and oral health behavior in Chinese children with cleft lip and/or palate. Pediatr Dent. 2001; 23(5):431-4. View

14.

Kirchberg A, Makuch A, Hemprich A, Hirsch C . Dental caries in the primary dentition of german children with cleft lip, alveolus, and palate. Cleft Palate Craniofac J. 2012; 51(3):308-13. DOI: 10.1597/12-106. View

15.

Al-Dajani M . Comparison of dental caries prevalence in patients with cleft lip and/or palate and their sibling controls. Cleft Palate Craniofac J. 2010; 46(5):529-31. DOI: 10.1597/08-003.1. View

16.

Petersen P, Bourgeois D, Ogawa H, Estupinan-Day S, Ndiaye C . The global burden of oral diseases and risks to oral health. Bull World Health Organ. 2005; 83(9):661-9. PMC: 2626328. DOI: /S0042-96862005000900011. View

17.

Hazzaa A, Rawashdeh M, Al-Nimri K, Al Habashneh R . Dental and oral hygiene status in Jordanian children with cleft lip and palate: a comparison between unilateral and bilateral clefts. Int J Dent Hyg. 2011; 9(1):30-6. DOI: 10.1111/j.1601-5037.2009.00426.x. View

18.

Hasslof P, Twetman S . Caries prevalence in children with cleft lip and palate--a systematic review of case-control studies. Int J Paediatr Dent. 2007; 17(5):313-9. DOI: 10.1111/j.1365-263X.2007.00847.x. View

19.

Ahluwalia M, Brailsford S, Tarelli E, Gilbert S, Clark D, Barnard K . Dental caries, oral hygiene, and oral clearance in children with craniofacial disorders. J Dent Res. 2004; 83(2):175-9. DOI: 10.1177/154405910408300218. View

20.

Hochstein U, HOCHSTEIN H . [Caries statistical studies in 1198 children with cleft lips and cleft palates]. Dtsch Zahn Mund Kieferheilkd Zentralbl Gesamte. 1970; 55(5):134-41. View