Thirteen Novel Canine Dog Leukocyte Antigen-88 Alleles Identified by Sequence-based Typing

Overview

Journal HLA

Date 2017 Jul 6

PMID 28677267

Citations 14

Authors

G M Venkataraman

L J Kennedy

M-T E Little

S S Graves

M A Harkey

B J Torok-Storb

R Storb

Affiliations

Soon will be listed here.

Abstract

Major histocompatibility complex (MHC) genes in mammals include highly polymorphic class I and class II genes that are critical for donor-recipient matching for transplantation. Dogs have served as an effective, directly translatable model for stem/progenitor cell transplantation. Previous analyses of MHC class I genes in dogs point to a single highly polymorphic gene, dog leukocyte antigen (DLA)-88, as an important factor in the success or failure of hematopoietic stem cell transplants. Fifty-nine DLA-88 alleles have been identified and reported so far. Here, we extend this list by presenting 13 novel DLA-88 alleles found in domestic dogs.

Citing Articles

Large-Scale Polymorphism Analysis of Dog Leukocyte Antigen Class I and Class II Genes (, and ) and Comparison of the Haplotype Diversity between Breeds in Japan.

Miyamae J, Okano M, Katakura F, Kulski J, Moritomo T, Shiina T Cells. 2023; 12(5).

PMID: 36899945 PMC: 10001263. DOI: 10.3390/cells12050809.

Genotyping of canine MHC gene DLA-88 by next-generation sequencing reveals high frequencies of new allele discovery and gene duplication.

Pyo C, Harkey M, Torok-Storb B, Storb R, Wang R, Thomas A HLA. 2022; 100(5):479-490.

PMID: 36227705 PMC: 9563979. DOI: 10.1111/tan.14752.

Allogeneic peripheral blood haematopoietic stem cell transplantation for the treatment of dogs with high-grade B-cell lymphoma.

Gareau A, Sekiguchi T, Warry E, Ripoll A, Sullivan E, Westfall T Vet Comp Oncol. 2022; 20(4):862-870.

PMID: 35789057 PMC: 9796125. DOI: 10.1111/vco.12847.

Haplotype structures and polymorphisms of dog leukocyte antigen (DLA) class I loci shaped by intralocus and interlocus recombination events.

Miyamae J, Okano M, Nishiya K, Katakura F, Kulski J, Moritomo T Immunogenetics. 2022; 74(2):245-259.

PMID: 34993565 DOI: 10.1007/s00251-021-01234-5.

Immunosuppression-enhancing effect of the administration of allogeneic canine adipose-derived mesenchymal stem cells (cA-MSCs) compared with autologous cA-MSCs .

Wi H, Lee S, Kim Y, No J, Lee P, Lee B J Vet Sci. 2021; 22(5):e63.

PMID: 34423601 PMC: 8460457. DOI: 10.4142/jvs.2021.22.e63.

References

Little M, Storb R . History of haematopoietic stem-cell transplantation. Nat Rev Cancer. 2002; 2(3):231-8. DOI: 10.1038/nrc748. View

Burnett R, DeRose S, Wagner J, Storb R . Molecular analysis of six dog leukocyte antigen class I sequences including three complete genes, two truncated genes and one full-length processed gene. Tissue Antigens. 1997; 49(5):484-95. DOI: 10.1111/j.1399-0039.1997.tb02783.x. View

Venkataraman G, Stroup P, Graves S, Storb R . An improved method for dog leukocyte antigen 88 typing and two new major histocompatibility complex class I alleles, DLA-88*01101 and DLA-88*01201. Tissue Antigens. 2007; 70(1):53-7. DOI: 10.1111/j.1399-0039.2007.00839.x. View

Burnett R, Geraghty D . Structure and expression of a divergent canine class I gene. J Immunol. 1995; 155(9):4278-85. View

Chenna R, Sugawara H, Koike T, Lopez R, Gibson T, Higgins D . Multiple sequence alignment with the Clustal series of programs. Nucleic Acids Res. 2003; 31(13):3497-500. PMC: 168907. DOI: 10.1093/nar/gkg500. View

Hardt C, Ferencik S, Tak R, Hoogerbrugge P, WAGNER V, Grosse-Wilde H . Sequence-based typing reveals a novel DLA-88 allele, DLA-88*04501, in a beagle family. Tissue Antigens. 2006; 67(2):163-5. DOI: 10.1111/j.1399-0039.2006.00497.x. View

Dereeper A, Guignon V, Blanc G, Audic S, Buffet S, Chevenet F . Phylogeny.fr: robust phylogenetic analysis for the non-specialist. Nucleic Acids Res. 2008; 36(Web Server issue):W465-9. PMC: 2447785. DOI: 10.1093/nar/gkn180. View

Ross P, Buntzman A, Vincent B, Grover E, Gojanovich G, Collins E . Allelic diversity at the DLA-88 locus in Golden Retriever and Boxer breeds is limited. Tissue Antigens. 2012; 80(2):175-83. PMC: 3407292. DOI: 10.1111/j.1399-0039.2012.01889.x. View

Venkataraman G, Geraghty D, Fox J, Graves S, Zellmer E, Storer B . Canine DLA-79 gene: an improved typing method, identification of new alleles and its role in graft rejection and graft-versus-host disease. Tissue Antigens. 2013; 81(4):204-11. PMC: 3605710. DOI: 10.1111/tan.12094. View

10.

Baron F, Storb R, Little M . Hematopoietic cell transplantation: five decades of progress. Arch Med Res. 2004; 34(6):528-44. DOI: 10.1016/j.arcmed.2003.09.010. View

11.

Graumann M, DeRose S, Ostrander E, Storb R . Polymorphism analysis of four canine MHC class I genes. Tissue Antigens. 1998; 51(4 Pt 1):374-81. DOI: 10.1111/j.1399-0039.1998.tb02976.x. View

12.

Wagner J, Sarmiento U, Storb R . Cellular, serological, and molecular polymorphism of the class I and class II loci of the canine Major Histocompatibility Complex. Tissue Antigens. 2002; 59(3):205-10. DOI: 10.1034/j.1399-0039.2002.590304.x. View

13.

Ellis S, Bontrop R, Antczak D, Ballingall K, Davies C, Kaufman J . ISAG/IUIS-VIC Comparative MHC Nomenclature Committee report, 2005. Immunogenetics. 2006; 57(12):953-8. DOI: 10.1007/s00251-005-0071-4. View

14.

Tsai K, Starr-Moss A, Venkataraman G, Robinson C, Kennedy L, Steiner J . Alleles of the major histocompatibility complex play a role in the pathogenesis of pancreatic acinar atrophy in dogs. Immunogenetics. 2013; 65(7):501-9. PMC: 3857963. DOI: 10.1007/s00251-013-0704-y. View

15.

Jochum C, Beste M, Zellmer E, Graves S, Storb R . CD154 blockade and donor-specific transfusions in DLA-identical marrow transplantation in dogs conditioned with 1-Gy total body irradiation. Biol Blood Marrow Transplant. 2007; 13(2):164-71. PMC: 1831459. DOI: 10.1016/j.bbmt.2006.10.031. View

16.

Wagner J, Creer S, Storb R . Dog class I gene DLA-88 histocompatibility typing by PCR-SSCP and sequencing. Tissue Antigens. 2000; 55(6):564-7. DOI: 10.1034/j.1399-0039.2000.550607.x. View

17.

Kennedy L, Angles J, Barnes A, Carter S, Francino O, Gerlach J . Nomenclature for factors of the dog major histocompatibility system (DLA), 2000: Second report of the ISAG DLA Nomenclature Committee. Tissue Antigens. 2001; 58(1):55-70. DOI: 10.1034/j.1399-0039.2001.580111.x. View

18.

EPSTEIN R, Storb R, RAGDE H, Thomas E . Cytotoxic typing antisera for marrow grafting in littermate dogs. Transplantation. 1968; 6(1):45-58. DOI: 10.1097/00007890-196801000-00005. View

19.

Storb R, Rudolph R, Thomas E . Marrow grafts between canine siblings matched by serotyping and mixed leukocyte culture. J Clin Invest. 1971; 50(6):1272-5. PMC: 292057. DOI: 10.1172/JCI106605. View

20.

Storb R, Yu C, Barnett T, Wagner J, Deeg H, Nash R . Stable mixed hematopoietic chimerism in dog leukocyte antigen-identical littermate dogs given lymph node irradiation before and pharmacologic immunosuppression after marrow transplantation. Blood. 1999; 94(3):1131-6. View