Host Determinants of Adeno-associated Viral Vector Entry

Overview

Journal Curr Opin Virol

Publisher Elsevier

Specialty Microbiology

Date 2017 Jul 4

PMID 28672171

Citations 38

Authors

Sirika Pillay

Jan E Carette

Affiliations

Soon will be listed here.

Abstract

Viral vectors based on adeno-associated virus (AAV) are leading candidates for therapeutic gene delivery. Understanding rate-limiting steps in the entry of AAV vectors may be used in a rational approach to improve efficiency and specificity of transduction. This review describes our current understanding of AAV entry, a key step during infection. We discuss the identity and functions of AAV receptors and attachment factors, including the recently discovered multi-serotype receptor AAVR. We further provide an overview of other host factors that act during the trafficking stage of AAV vector transduction. In particular, we focus on cellular protein complexes associated with retrograde transport from endosomes to the trans-Golgi network. The novel insights in AAV-host interactions facilitated by technological advances in genetic screening approaches provide a greater depth in our understanding how AAV vectors exploit host factors to deliver its genetic cargo to the nucleus.

Citing Articles

A review of virus host factor discovery using CRISPR screening.

See W, Yousefi M, Ooi Y mBio. 2024; 15(11):e0320523.

PMID: 39422472 PMC: 11559068. DOI: 10.1128/mbio.03205-23.

Globoside Is an Essential Intracellular Factor Required for Parvovirus B19 Endosomal Escape.

Bieri J, Suter C, Caliaro O, Bartetzko S, Bircher C, Ros C Cells. 2024; 13(15.

PMID: 39120285 PMC: 11311400. DOI: 10.3390/cells13151254.

Adeno-Associated Virus Engineering and Load Strategy for Tropism Modification, Immune Evasion and Enhanced Transgene Expression.

Zhou X, Liu J, Xiao S, Liang X, Li Y, Mo F Int J Nanomedicine. 2024; 19:7691-7708.

PMID: 39099791 PMC: 11296317. DOI: 10.2147/IJN.S459905.

Thrombotic Microangiopathy as an Emerging Complication of Viral Vector-Based Gene Therapy.

Schwotzer N, El Sissy C, Desguerre I, Fremeaux-Bacchi V, Servais L, Fakhouri F Kidney Int Rep. 2024; 9(7):1995-2005.

PMID: 39081755 PMC: 11284364. DOI: 10.1016/j.ekir.2024.04.024.

The laminin receptor is a receptor for rhabdovirus.

Luo S, Liang J, Yang G, Lu J, Chen J J Virol. 2024; 98(7):e0069724.

PMID: 38916400 PMC: 11265286. DOI: 10.1128/jvi.00697-24.

References

Nelson C, Hakim C, Ousterout D, Thakore P, Moreb E, Castellanos Rivera R . In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy. Science. 2016; 351(6271):403-7. PMC: 4883596. DOI: 10.1126/science.aad5143. View

Nonnenmacher M, Cintrat J, Gillet D, Weber T . Syntaxin 5-dependent retrograde transport to the trans-Golgi network is required for adeno-associated virus transduction. J Virol. 2014; 89(3):1673-87. PMC: 4300741. DOI: 10.1128/JVI.02520-14. View

Ding W, Zhang L, Yeaman C, Engelhardt J . rAAV2 traffics through both the late and the recycling endosomes in a dose-dependent fashion. Mol Ther. 2006; 13(4):671-82. PMC: 1712670. DOI: 10.1016/j.ymthe.2005.12.002. View

Akache B, Grimm D, Shen X, Fuess S, Yant S, Glazer D . A two-hybrid screen identifies cathepsins B and L as uncoating factors for adeno-associated virus 2 and 8. Mol Ther. 2007; 15(2):330-9. PMC: 7106033. DOI: 10.1038/sj.mt.6300053. View

Huang L, Halder S, Agbandje-Mckenna M . Parvovirus glycan interactions. Curr Opin Virol. 2014; 7:108-18. PMC: 4149944. DOI: 10.1016/j.coviro.2014.05.007. View

Guglielmi K, Johnson E, Stehle T, Dermody T . Attachment and cell entry of mammalian orthoreovirus. Curr Top Microbiol Immunol. 2006; 309:1-38. DOI: 10.1007/3-540-30773-7_1. View

Summerford C, Samulski R . Membrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virions. J Virol. 1998; 72(2):1438-45. PMC: 124624. DOI: 10.1128/JVI.72.2.1438-1445.1998. View

Ibraghimov-Beskrovnaya O, Bukanov N, Donohue L, Dackowski W, Klinger K, Landes G . Strong homophilic interactions of the Ig-like domains of polycystin-1, the protein product of an autosomal dominant polycystic kidney disease gene, PKD1. Hum Mol Genet. 2000; 9(11):1641-9. DOI: 10.1093/hmg/9.11.1641. View

Summerford C, Bartlett J, Samulski R . AlphaVbeta5 integrin: a co-receptor for adeno-associated virus type 2 infection. Nat Med. 1999; 5(1):78-82. DOI: 10.1038/4768. View

10.

Ran F, Cong L, Yan W, Scott D, Gootenberg J, Kriz A . In vivo genome editing using Staphylococcus aureus Cas9. Nature. 2015; 520(7546):186-91. PMC: 4393360. DOI: 10.1038/nature14299. View

11.

Sanlioglu S, Benson P, Yang J, Atkinson E, Reynolds T, Engelhardt J . Endocytosis and nuclear trafficking of adeno-associated virus type 2 are controlled by rac1 and phosphatidylinositol-3 kinase activation. J Virol. 2000; 74(19):9184-96. PMC: 102117. DOI: 10.1128/jvi.74.19.9184-9196.2000. View

12.

Bantel-Schaal U, Hub B, Kartenbeck J . Endocytosis of adeno-associated virus type 5 leads to accumulation of virus particles in the Golgi compartment. J Virol. 2002; 76(5):2340-9. PMC: 153830. DOI: 10.1128/jvi.76.5.2340-2349.2002. View

13.

Popa A, Zhang W, Harrison M, Goodner K, Kazakov T, Goodwin E . Direct binding of retromer to human papillomavirus type 16 minor capsid protein L2 mediates endosome exit during viral infection. PLoS Pathog. 2015; 11(2):e1004699. PMC: 4334968. DOI: 10.1371/journal.ppat.1004699. View

14.

Samulski R, Muzyczka N . AAV-Mediated Gene Therapy for Research and Therapeutic Purposes. Annu Rev Virol. 2016; 1(1):427-51. DOI: 10.1146/annurev-virology-031413-085355. View

15.

Kashiwakura Y, Tamayose K, Iwabuchi K, Hirai Y, Shimada T, Matsumoto K . Hepatocyte growth factor receptor is a coreceptor for adeno-associated virus type 2 infection. J Virol. 2004; 79(1):609-14. PMC: 538679. DOI: 10.1128/JVI.79.1.609-614.2005. View

16.

Bowles D, McPhee S, Li C, Gray S, Samulski J, Camp A . Phase 1 gene therapy for Duchenne muscular dystrophy using a translational optimized AAV vector. Mol Ther. 2011; 20(2):443-55. PMC: 3277234. DOI: 10.1038/mt.2011.237. View

17.

Madigan V, Asokan A . Engineering AAV receptor footprints for gene therapy. Curr Opin Virol. 2016; 18:89-96. PMC: 6537878. DOI: 10.1016/j.coviro.2016.05.001. View

18.

Ling C, Lu Y, Kalsi J, Jayandharan G, Li B, Ma W . Human hepatocyte growth factor receptor is a cellular coreceptor for adeno-associated virus serotype 3. Hum Gene Ther. 2010; 21(12):1741-7. PMC: 2999576. DOI: 10.1089/hum.2010.075. View

19.

Carette J, Guimaraes C, Varadarajan M, Park A, Wuethrich I, Godarova A . Haploid genetic screens in human cells identify host factors used by pathogens. Science. 2009; 326(5957):1231-5. DOI: 10.1126/science.1178955. View

20.

Pillay S, Carette J . Hunting Viral Receptors Using Haploid Cells. Annu Rev Virol. 2016; 2(1):219-39. PMC: 4982367. DOI: 10.1146/annurev-virology-100114-055119. View