Lung As a Niche for Hematopoietic Progenitors

Overview

Journal Stem Cell Rev Rep

Publisher Springer

Specialty Cell Biology

Date 2017 Jul 3

PMID 28669077

Citations 44

Authors

Isabella Borges

Isadora Sena

Patrick Azevedo

Julia Andreotti

Viviani Almeida

Ana Paiva

Gabryella Santos

Daniel Guerra

Pedro Prazeres

Luiza Lousado Mesquita

Luanny Souto de Barros Silva

Caroline Leonel

Akiva Mintz

Alexander Birbrair

Affiliations

Soon will be listed here.

Abstract

Platelets are released from megakaryocytes. The bone marrow has been proposed to be the major site where this process occurs. Lefrançais et al. (2017) using state-of-the-art techniques including two-photon microscopy, in vivo lineage-tracing technologies, and sophisticated lung transplants reveal that the lung is also a primary site for platelet biogenesis. Strikingly, lung megakaryocytes can completely reconstitute platelet counts in the blood in mice with thrombocytopenia. This study also shows that hematopoietic progenitors, with capacity to repopulate the bone marrow after irradiation, are present in the lungs. This work brings a novel unexpected role for the lung as a niche for hematopoiesis. The emerging knowledge from this research may be important for the treatment of several disorders.

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