Ecogenetics of Parkinson's Disease: 4-hydroxylation of Debrisoquine

Overview

Journal Lancet

Publisher Elsevier

Specialty General Medicine

Date 1985 Nov 30

PMID 2866293

Citations 32

Authors

A Barbeau

T Cloutier

M Roy

L Plasse

S Paris

J Poirier

Affiliations

Soon will be listed here.

Abstract

It is postulated that Parkinson's disease is the result of environmental factors acting on genetically susceptible individuals against a background of normal ageing. Many potentially neurotoxic xenobiotics are detoxified by hepatic cytochrome P450. The function of one such system was studied in forty patients with Parkinson's disease and forty normal control subjects. Significantly more parkinsonian than control subjects had partially or totally defective 4-hydroxylation of debrisoquine. Poor metabolisers of debrisoquine tended to have had earlier onset of disease.

Citing Articles

Lessons Learned From Past Gene-Environment Interaction Successes.

Ritz B, Chatterjee N, Garcia-Closas M, Gauderman W, Pierce B, Kraft P Am J Epidemiol. 2017; 186(7):778-786.

PMID: 28978190 PMC: 5860326. DOI: 10.1093/aje/kwx230.

CYP2D6*4 allele polymorphism increases the risk of Parkinson's disease: evidence from meta-analysis.

Lu Y, Mo C, Zeng Z, Chen S, Xie Y, Peng Q PLoS One. 2013; 8(12):e84413.

PMID: 24376807 PMC: 3869836. DOI: 10.1371/journal.pone.0084413.

Acetaldehyde and parkinsonism: role of CYP450 2E1.

Vaglini F, Viaggi C, Piro V, Pardini C, Gerace C, Scarselli M Front Behav Neurosci. 2013; 7:71.

PMID: 23801948 PMC: 3689266. DOI: 10.3389/fnbeh.2013.00071.

3,4-Dehydrodebrisoquine, a novel debrisoquine metabolite formed from 4-hydroxydebrisoquine that affects the CYP2D6 metabolic ratio.

Zhen Y, Slanar O, Krausz K, Chen C, Slavik J, McPhail K Drug Metab Dispos. 2006; 34(9):1563-74.

PMID: 16782768 PMC: 1553181. DOI: 10.1124/dmd.105.008920.

Potential role of cerebral cytochrome P450 in clinical pharmacokinetics: modulation by endogenous compounds.

Gervasini G, Carrillo J, Benitez J Clin Pharmacokinet. 2004; 43(11):693-706.

PMID: 15301574 DOI: 10.2165/00003088-200443110-00001.