Biomarker Research in Neurotoxicology: the Role of Mechanistic Studies to Bridge the Gap Between the Laboratory and Epidemiological Investigations

Overview

Journal Environ Health Perspect

Date 1996 Mar 1

PMID 8722110

Citations 10

Authors

L G Costa

Affiliations

Soon will be listed here.

Abstract

There is an increasing interest in the development and validation of biomarkers for use in biochemical/molecular epidemiological studies. Though the area of neurotoxicology has received much attention in the past several years, it still lags behind with regard to the development of biomarkers, particularly those of health effects and susceptibility. This review discusses several aspects of biomarker research as it relates to neurotoxic compounds and focuses on selected agents (organophosphorus insecticides, styrene, n-hexane, carbon disulfide, acrylamide), which have been the subject of a number of investigations in animals and humans. While traditional biomonitoring approaches and novel techniques (e.g., hemoglobin adducts) provide several measurements for monitoring exposure to neurotoxic chemicals, potential markers of genetic susceptibility have been seldom investigated in a neurotoxicology context. Furthermore, the complexity of the nervous system, together with the multiplicity of end points and the limited knowledge of the exact mechanism(s) of action of neurotoxicants, has led to only limited advancements in the development of biomarkers for neurotoxic effects. Significant progress in this area will depend upon an increased understanding of the cellular, biochemical, and molecular targets directly involved in neurotoxicity.

Citing Articles

Environmental Styrene Exposure and Sensory and Motor Function in Gulf Coast Residents.

Werder E, Sandler D, Richardson D, Emch M, Kwok R, Gerr F Environ Health Perspect. 2019; 127(4):47006.

PMID: 31009265 PMC: 6785236. DOI: 10.1289/EHP3954.

Environmental styrene exposure and neurologic symptoms in U.S. Gulf coast residents.

Werder E, Engel L, Richardson D, Emch M, Gerr F, Kwok R Environ Int. 2018; 121(Pt 1):480-490.

PMID: 30278311 PMC: 6712572. DOI: 10.1016/j.envint.2018.09.025.

Manganese in human parenteral nutrition: considerations for toxicity and biomonitoring.

Santos D, Batoreu C, Mateus L, Dos Santos A, Aschner M Neurotoxicology. 2013; 43:36-45.

PMID: 24184781 PMC: 4007395. DOI: 10.1016/j.neuro.2013.10.003.

Protein adducts as biomarkers of exposure to organophosphorus compounds.

Marsillach J, Costa L, Furlong C Toxicology. 2012; 307:46-54.

PMID: 23261756 PMC: 3747771. DOI: 10.1016/j.tox.2012.12.007.

Proteomic analysis of adducted butyrylcholinesterase for biomonitoring organophosphorus exposures.

Marsillach J, Hsieh E, Richter R, MacCoss M, Furlong C Chem Biol Interact. 2012; 203(1):85-90.

PMID: 23123252 PMC: 4108156. DOI: 10.1016/j.cbi.2012.10.019.

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