Origin of Human T-lymphotrophic Virus I-positive T Cell Lines in Adult T Cell Leukemia. Analysis of T Cell Receptor Gene Rearrangement

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1985 Dec 1

PMID 2866223

Citations 68

Authors

M Maeda

A Shimizu

K Ikuta

H Okamoto

M Kashihara

T Uchiyama

T Honjo

J Yodoi

Affiliations

Soon will be listed here.

Abstract

Using the clone-specific rearrangement of the T cell receptor gene as the genetic marker of the clonotype, we analyzed the clonal origin of the interleukin 2 (IL-2)-dependent human T-lymphotrophic virus I (HTLV-I)-positive T cell lines established from various adult T cell leukemia (ATL) patients. From a patient with chronic ATL, whose leukemic cells proliferated in vitro in response to IL-2, we repeatedly established leukemic T cell clones having the same rearrangement profile of the T beta chain gene as the leukemic cells. By contrast, established cell lines from acute ATL patients had different beta chain gene rearrangements from those of the leukemic cells. These HTLV-I+ T cell lines might not be the direct progeny of the leukemic cells, but that of T cells infected either in vivo or in vitro. These IL-2-reactive nonleukemic T cells might have been selected in vitro, because their leukemic cells failed to respond to IL-2, despite the expression of IL-2 receptor. The analysis of the T cell receptor gene rearrangement may give a new approach for the elucidation of the mechanism of leukemogenesis and the origin of the HTLV-I+ T cell lines in ATL.

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References

Nikaido T, Shimizu A, Ishida N, Sabe H, Teshigawara K, Maeda M . Molecular cloning of cDNA encoding human interleukin-2 receptor. Nature. 1984; 311(5987):631-5. DOI: 10.1038/311631a0. View

Leonard W, Depper J, Crabtree G, Rudikoff S, Pumphrey J, Robb R . Molecular cloning and expression of cDNAs for the human interleukin-2 receptor. Nature. 1984; 311(5987):626-31. DOI: 10.1038/311626a0. View

Smith K, Cantrell D . Interleukin 2 regulates its own receptors. Proc Natl Acad Sci U S A. 1985; 82(3):864-8. PMC: 397147. DOI: 10.1073/pnas.82.3.864. View

Yodoi J, Okada M, Tagaya Y, Teshigawara K, Fukui K, Ishida N . Rat lymphoid cell lines producing human T cell leukemia virus. II. Constitutive expression of rat interleukin 2 receptor. J Exp Med. 1985; 161(5):924-34. PMC: 2187610. DOI: 10.1084/jem.161.5.924. View

Uchiyama T, Hori T, Tsudo M, Wano Y, Umadome H, Tamori S . Interleukin-2 receptor (Tac antigen) expressed on adult T cell leukemia cells. J Clin Invest. 1985; 76(2):446-53. PMC: 423837. DOI: 10.1172/JCI111992. View

Yodoi J, Takatsuki K, Masuda T . Letter: Two cases of T-cell chronic lymphocytic leukemia in Japan. N Engl J Med. 1974; 290(10):572-3. DOI: 10.1056/NEJM197403072901018. View

Smith K . T-cell growth factor. Immunol Rev. 1980; 51:337-57. DOI: 10.1111/j.1600-065x.1980.tb00327.x. View

Uchiyama T, Broder S, Waldmann T . A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. I. Production of anti-Tac monoclonal antibody and distribution of Tac (+) cells. J Immunol. 1981; 126(4):1393-7. View

Poiesz B, Ruscetti F, Gazdar A, Bunn P, Minna J, Gallo R . Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci U S A. 1980; 77(12):7415-9. PMC: 350514. DOI: 10.1073/pnas.77.12.7415. View

10.

Hinuma Y, Nagata K, Hanaoka M, Nakai M, Matsumoto T, Kinoshita K . Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera. Proc Natl Acad Sci U S A. 1981; 78(10):6476-80. PMC: 349062. DOI: 10.1073/pnas.78.10.6476. View

11.

Yoshida M, Miyoshi I, Hinuma Y . Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease. Proc Natl Acad Sci U S A. 1982; 79(6):2031-5. PMC: 346116. DOI: 10.1073/pnas.79.6.2031. View

12.

Tsudo M, Uchiyama T, Uchino H, Yodoi J . Failure of regulation of Tac antigen/TCGF receptor on adult T-cell leukemia cells by anti-Tac monoclonal antibody. Blood. 1983; 61(5):1014-6. View

13.

Seiki M, Hattori S, Hirayama Y, Yoshida M . Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA. Proc Natl Acad Sci U S A. 1983; 80(12):3618-22. PMC: 394101. DOI: 10.1073/pnas.80.12.3618. View

14.

Yodoi J, Uchiyama T, Maeda M . T-cell growth factor receptor in adult T-cell leukemia. Blood. 1983; 62(2):509-11. View

15.

Hedrick S, Cohen D, Nielsen E, Davis M . Isolation of cDNA clones encoding T cell-specific membrane-associated proteins. Nature. 1984; 308(5955):149-53. DOI: 10.1038/308149a0. View

16.

Siu G, Clark S, Yoshikai Y, Malissen M, Yanagi Y, Strauss E . The human T cell antigen receptor is encoded by variable, diversity, and joining gene segments that rearrange to generate a complete V gene. Cell. 1984; 37(2):393-401. DOI: 10.1016/0092-8674(84)90369-6. View

17.

Hahn B, Gallo R, Franchini G, Popovic M, Aoki T, Salahuddin S . Clonal selection of human T-cell leukemia virus-infected cells in vivo and in vitro. Mol Biol Med. 1984; 2(1):29-36. View