Linoleic Acid Participates in the Response to Ischemic Brain Injury Through Oxidized Metabolites That Regulate Neurotransmission

Overview

Journal Sci Rep

Specialty Science

Date 2017 Jun 30

PMID 28659576

Citations 25

Authors

Marie Hennebelle

Zhichao Zhang

Adam H Metherel

Alex P Kitson

Yurika Otoki

Christine E Richardson

Jun Yang

Kin Sing Stephen Lee

Bruce D Hammock

Liang Zhang

Richard P Bazinet

Ameer Y Taha

Affiliations

Soon will be listed here.

Abstract

Linoleic acid (LA; 18:2 n-6), the most abundant polyunsaturated fatty acid in the US diet, is a precursor to oxidized metabolites that have unknown roles in the brain. Here, we show that oxidized LA-derived metabolites accumulate in several rat brain regions during CO-induced ischemia and that LA-derived 13-hydroxyoctadecadienoic acid, but not LA, increase somatic paired-pulse facilitation in rat hippocampus by 80%, suggesting bioactivity. This study provides new evidence that LA participates in the response to ischemia-induced brain injury through oxidized metabolites that regulate neurotransmission. Targeting this pathway may be therapeutically relevant for ischemia-related conditions such as stroke.

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