The Effect of Obesity and Repeated Exposure on Pharmacokinetic Response to Grape Polyphenols in Humans

Overview

Journal Mol Nutr Food Res

Specialty Nutritional Sciences

Date 2017 Jun 28

PMID 28654207

Citations 13

Authors

Janet A Novotny

Tzu-Ying Chen

Anton I Terekhov

Sarah K Gebauer

David J Baer

Lap Ho

Giulio M Pasinetti

Mario G Ferruzzi

Affiliations

Soon will be listed here.

Abstract

Scope: Evidence suggests that dietary pattern may affect polyphenol absorption and/or metabolism. Further, obesity is associated with lower circulating nutrients, though the reason is unclear. We investigated the pharmacokinetic (PK) response of polyphenols in obese/overweight versus lean individuals before and after repeated dosing of grape polyphenols.

Methods And Results: A pilot study was conducted in which PK challenges were administered before and after 10 days of repeated dosing with polyphenols. Volunteers (6 lean, 6 overweight/obese) consumed resveratrol, grape seed extract, and grape juice (2125 mg total polyphenols) daily. On days 1 and 11, blood samples were collected for 6 h after the polyphenol dose and analyzed for deconjugated catechin, epicatechin, resveratrol, and quercetin. Area under the plasma polyphenol mass by time curves (AUCs) were greater for catechin, epicatechin, and quercetin on day 11 versus day 1 for low BMI individuals (p = 0.039) but not high BMI individuals. Further, AUCs were greater for epicatechin and resveratrol for low versus high BMI individuals (p = 0.041), with a similar trend for catechin (p = 0.065), on day 11 but not day 1.

Conclusion: These results suggest that that obesity and repeated exposure may modify polyphenol absorption and/or metabolism in humans.

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