Mapping the Glyco-Gold Nanoparticles of Different Shapes Toxicity, Biodistribution and Sequestration in Adult Zebrafish

Overview

Journal Sci Rep

Specialty Science

Date 2017 Jun 28

PMID 28652584

Citations 14

Authors

Sivakoti Sangabathuni

Raghavendra Vasudeva Murthy

Preeti Madhukar Chaudhary

Balamurugan Subramani

Suraj Toraskar

Raghavendra Kikkeri

Affiliations

Soon will be listed here.

Abstract

Glyconanotechnology offers a broad range of applications across basic and translation research. Despite the tremendous progress in glyco-nanomaterials, there is still a huge gap between the basic research and therapeutic applications of these molecules. It has been reported that complexity and the synthetic challenges in glycans synthesis, the cost of the high order in vivo models and large amount of sample consumptions limited the effort to translate the glyco-nanomaterials into clinical applications. In this regards, several promising simple animal models for preliminary, quick analysis of the nanomaterials activities has been proposed. Herein, we have studied a systematic evaluation of the toxicity, biodistribution of fluorescently tagged PEG and mannose-capped gold nanoparticles (AuNPs) of three different shapes (sphere, rod, and star) in the adult zebrafish model, which could accelerate and provide preliminary results for further experiments in the higher order animal system. ICP-MS analysis and confocal images of various zebrafish organs revealed that rod-AuNPs exhibited the fast uptake. While, star-AuNPs displayed prolong sequestration, demonstrating its potential therapeutic efficacy in drug delivery.

Citing Articles

Enhancing Proton Therapy Efficacy Through Nanoparticle-Mediated Radiosensitization.

Ma J, Shen H, Mi Z Cells. 2024; 13(22).

PMID: 39594590 PMC: 11593106. DOI: 10.3390/cells13221841.

Combination chemotherapy via poloxamer 188 surface-modified PLGA nanoparticles that traverse the blood-brain-barrier in a glioblastoma model.

Madani F, Morovvati H, Webster T, Najaf Asaadi S, Rezayat S, Hadjighassem M Sci Rep. 2024; 14(1):19516.

PMID: 39174603 PMC: 11341868. DOI: 10.1038/s41598-024-69888-1.

Silver Nanoparticles Encapped by Dihydromyricetin: Optimization of Green Synthesis, Characterization, Toxicity, and Anti-MRSA Infection Activities for Zebrafish ().

Qi L, Wang X, Huang J, Yue T, Lu Y, San D Int J Mol Sci. 2024; 25(10).

PMID: 38791295 PMC: 11120860. DOI: 10.3390/ijms25105255.

Development of Hemagglutinin-Neuraminidase Homologous Peptides as Novel Promising Therapeutic Agents Against Peste des Petits Ruminants Virus.

Agrawal A, Varshney R, Gattani A, Khan M, Gupta R, Solanki K Protein J. 2023; 42(6):685-697.

PMID: 37421558 DOI: 10.1007/s10930-023-10134-4.

Shape-dependent gold nanoparticle interactions with a model cell membrane.

Golbek T, Harper B, Harper S, Baio J Biointerphases. 2022; 17(6):061003.

PMID: 36347646 PMC: 9646251. DOI: 10.1116/6.0002183.

References

Li J, Ha H, Guo L, Coomber D, Chang Y . Discovery of novel zebrafish neural tracers by organism-based screening of a rosamine library. Chem Commun (Camb). 2010; 46(17):2932-4. DOI: 10.1039/b920432f. View

Newman M, Ebrahimie E, Lardelli M . Using the zebrafish model for Alzheimer's disease research. Front Genet. 2014; 5:189. PMC: 4075077. DOI: 10.3389/fgene.2014.00189. View

Safari D, Marradi M, Chiodo F, Th Dekker H, Shan Y, Adamo R . Gold nanoparticles as carriers for a synthetic Streptococcus pneumoniae type 14 conjugate vaccine. Nanomedicine (Lond). 2012; 7(5):651-62. DOI: 10.2217/nnm.11.151. View

Cohen M, Varki A . Modulation of glycan recognition by clustered saccharide patches. Int Rev Cell Mol Biol. 2014; 308:75-125. DOI: 10.1016/B978-0-12-800097-7.00003-8. View

Ohyanagi T, Nagahori N, Shimawaki K, Hinou H, Yamashita T, Sasaki A . Importance of sialic acid residues illuminated by live animal imaging using phosphorylcholine self-assembled monolayer-coated quantum dots. J Am Chem Soc. 2011; 133(32):12507-17. DOI: 10.1021/ja111201c. View

Kennedy D, Orts-Gil G, Lai C, Muller L, Haase A, Luch A . Carbohydrate functionalization of silver nanoparticles modulates cytotoxicity and cellular uptake. J Nanobiotechnology. 2014; 12:59. PMC: 4275941. DOI: 10.1186/s12951-014-0059-z. View

MacRae C, Peterson R . Zebrafish as tools for drug discovery. Nat Rev Drug Discov. 2015; 14(10):721-31. DOI: 10.1038/nrd4627. View

Chithrani B, Ghazani A, Chan W . Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells. Nano Lett. 2006; 6(4):662-8. DOI: 10.1021/nl052396o. View

Madhukar Chaudhary P, Sangabathuni S, Murthy R, Paul A, Thulasiram H, Kikkeri R . Assessing the effect of different shapes of glyco-gold nanoparticles on bacterial adhesion and infections. Chem Commun (Camb). 2015; 51(86):15669-72. DOI: 10.1039/c5cc05238f. View

10.

Lai C, Hutter J, Hsu C, Tanaka H, Varela-Aramburu S, De Cola L . Analysis of Carbohydrate-Carbohydrate Interactions Using Sugar-Functionalized Silicon Nanoparticles for Cell Imaging. Nano Lett. 2015; 16(1):807-11. DOI: 10.1021/acs.nanolett.5b04984. View

11.

Black K, Wang Y, Luehmann H, Cai X, Xing W, Pang B . Radioactive 198Au-doped nanostructures with different shapes for in vivo analyses of their biodistribution, tumor uptake, and intratumoral distribution. ACS Nano. 2014; 8(5):4385-94. PMC: 4358630. DOI: 10.1021/nn406258m. View

12.

Wang Y, Seebald J, Szeto D, Irudayaraj J . Biocompatibility and biodistribution of surface-enhanced Raman scattering nanoprobes in zebrafish embryos: in vivo and multiplex imaging. ACS Nano. 2010; 4(7):4039-53. DOI: 10.1021/nn100351h. View

13.

Li X, Liu B, Li X, Li Y, Sun M, Chen D . SiO2 nanoparticles change colour preference and cause Parkinson's-like behaviour in zebrafish. Sci Rep. 2014; 4:3810. PMC: 3898208. DOI: 10.1038/srep03810. View

14.

Delbianco M, Bharate P, Varela-Aramburu S, Seeberger P . Carbohydrates in Supramolecular Chemistry. Chem Rev. 2015; 116(4):1693-752. DOI: 10.1021/acs.chemrev.5b00516. View

15.

Gonzalez-Moragas L, Roig A, Laromaine A . C. elegans as a tool for in vivo nanoparticle assessment. Adv Colloid Interface Sci. 2015; 219:10-26. DOI: 10.1016/j.cis.2015.02.001. View

16.

van Kasteren S, Campbell S, Serres S, Anthony D, Sibson N, Davis B . Glyconanoparticles allow pre-symptomatic in vivo imaging of brain disease. Proc Natl Acad Sci U S A. 2008; 106(1):18-23. PMC: 2607245. DOI: 10.1073/pnas.0806787106. View

17.

Skjolding L, Asmonaite G, Jolck R, Andresen T, Selck H, Baun A . An assessment of the importance of exposure routes to the uptake and internal localisation of fluorescent nanoparticles in zebrafish (Danio rerio), using light sheet microscopy. Nanotoxicology. 2017; 11(3):351-359. DOI: 10.1080/17435390.2017.1306128. View

18.

Padmanabhan P, Kumar A, Kumar S, Chaudhary R, Gulyas B . Nanoparticles in practice for molecular-imaging applications: An overview. Acta Biomater. 2016; 41:1-16. DOI: 10.1016/j.actbio.2016.06.003. View

19.

Wang B, Chen N, Wei Y, Li J, Sun L, Wu J . Akt signaling-associated metabolic effects of dietary gold nanoparticles in Drosophila. Sci Rep. 2012; 2:563. PMC: 3413009. DOI: 10.1038/srep00563. View

20.

Zhu Z, Carboni R, Quercio Jr M, Yan B, Miranda O, Anderton D . Surface properties dictate uptake, distribution, excretion, and toxicity of nanoparticles in fish. Small. 2010; 6(20):2261-5. PMC: 3024600. DOI: 10.1002/smll.201000989. View