SiO2 Nanoparticles Change Colour Preference and Cause Parkinson's-like Behaviour in Zebrafish

Overview

Journal Sci Rep

Specialty Science

Date 2014 Jan 23

PMID 24448416

Citations 29

Authors

Xiang Li

Bo Liu

Xin-Le Li

Yi-Xiang Li

Ming-Zhu Sun

Dong-Yan Chen

Xin Zhao

Xi-Zeng Feng

Affiliations

Soon will be listed here.

Abstract

With advances in the development of various disciplines, there is a need to decipher bio-behavioural mechanisms via interdisciplinary means. Here, we present an interdisciplinary study of the role of silica nanoparticles (SiO2-NPs) in disturbing the neural behaviours of zebrafish and a possible physiological mechanism for this phenomenon. We used adult zebrafish as an animal model to evaluate the roles of size (15-nm and 50-nm) and concentration (300 μg/mL and 1000 μg/mL) in SiO2-NP neurotoxicity via behavioural and physiological analyses. With the aid of video tracking and data mining, we detected changes in behavioural phenotypes. We found that compared with 50-nm nanosilica, 15-nm SiO2-NPs produced greater significant changes in advanced cognitive neurobehavioural patterns (colour preference) and caused potentially Parkinson's disease-like behaviour. Analyses at the tissue, cell and molecular levels corroborated the behavioural results, demonstrating that nanosilica acted on the retina and dopaminergic (DA) neurons to change colour preference and to cause potentially Parkinson's disease-like behaviour.

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