Chemical Constituents with Proprotein Convertase Subtilisin/Kexin Type 9 MRNA Expression Inhibitory Activity from Dried Immature Morus Alba Fruits

Overview

Journal J Agric Food Chem

Specialties Chemistry
Nutritional Sciences

Date 2017 Jun 27

PMID 28649844

Citations 16

Authors

Pisey Pel

Hee-Sung Chae

Piseth Nhoek

Young-Mi Kim

Young-Won Chin

Affiliations

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Abstract

Phytochemical investigation for a chloroform-soluble extract of dried Morus alba fruits, selected by proprotein convertase subtilisin-kexin type 9 (PCSK9) mRNA expression monitoring assay in HepG2 cells, led to the isolation of a new benzofuran, isomoracin D (1), and a naturally occurring compound, N-(N-benzoyl-l-phenylalanyl)-l-phenylalanol (2), along with 13 known compounds (3-15). All of the structures were established by NMR spectroscopic data as well as MS analysis. Of the isolates, moracin C (7) was found to inhibit PCSK9 mRNA expression with an IC value of 16.8 μM in the HepG2 cells.

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