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No Evidence for Differences Between Pre- and Post-junctional Alpha 2-adrenoceptors

Overview
Journal Br J Pharmacol
Publisher Wiley
Specialty Pharmacology
Date 1985 Oct 1
PMID 2864971
Citations 9
Authors
J R Docherty
L HYLAND
Affiliations
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Abstract

We have examined the pre- and post-junctional effects of a series of alpha-adrenoceptor agonists and antagonists at alpha 2-adrenoceptors in the pithed rat preparation and the human isolated saphenous vein. In the pithed rat, there was no difference in relative agonist and antagonist potencies between pre- and post-junctional alpha 2-adrenoceptors but the absolute potencies of antagonists differed: antagonists were more potent prejunctionally. In the human saphenous vein, the alpha 2-adrenoceptor antagonist yohimbine had pre- and post-junctional actions over the same concentration range. We have no evidence to suggest differences between pre- and post-junctional alpha 2-adrenoceptors: differences in absolute antagonist potencies in the pithed rat may be due to non-equilibrium conditions.

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