NADPH Oxidases: Insights into Selected Functions and Mechanisms of Action in Cancer and Stem Cells

Overview

Journal Oxid Med Cell Longev

Publisher Wiley

Specialties Cell Biology
Endocrinology

Date 2017 Jun 20

PMID 28626501

Citations 62

Authors

Magdalena Skonieczna

Tomasz Hejmo

Aleksandra Poterala-Hejmo

Artur Cieslar-Pobuda

Rafal J Buldak

Affiliations

Soon will be listed here.

Abstract

NADPH oxidases (NOX) are reactive oxygen species- (ROS-) generating enzymes regulating numerous redox-dependent signaling pathways. NOX are important regulators of cell differentiation, growth, and proliferation and of mechanisms, important for a wide range of processes from embryonic development, through tissue regeneration to the development and spread of cancer. In this review, we discuss the roles of NOX and NOX-derived ROS in the functioning of stem cells and cancer stem cells and in selected aspects of cancer cell physiology. Understanding the functions and complex activities of NOX is important for the application of stem cells in tissue engineering, regenerative medicine, and development of new therapies toward invasive forms of cancers.

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