Value Assignment of Vitamin D Metabolites in Vitamin D Standardization Program Serum Samples

Overview

Journal J AOAC Int

Publisher Oxford University Press

Specialty Chemistry

Date 2017 Jun 18

PMID 28623654

Citations 2

Authors

Karen W Phinney

Johanna E Camara

Susan S-C Tai

Lane C Sander

Stephen A Wise

Linde A C De Grande

Linda M Thienpont

Antonio M Possolo

Blaza Toman

Christopher T Sempos

Joseph M Betz

Paul M Coates

Affiliations

Soon will be listed here.

Abstract

Assay variability has been cited as an obstacle to establishing optimal vitamin D exposure. As part of the Vitamin D Standardization Program (VDSP) effort to standardize the measurement of total 25-hydroxyvitamin D [25(OH)D], the value assignment of total 25(OH)D in 50 single-donor serum samples was performed using two isotope-dilution LC with tandem MS methods. Both methods are recognized as reference measurement procedures (RMPs) by the Joint Committee for Traceability in Laboratory Medicine. These samples and their assigned values serve as the foundation for several aspects of the VDSP. To our knowledge, this is the first time that two RMPs have been used to assign 25(OH)D values to such a large number of serum samples.

Citing Articles

Evolution and impact of Standard Reference Materials (SRMs) for determining vitamin D metabolites.

Wise S, Kuszak A, Camara J Anal Bioanal Chem. 2024; 416(9):2335-2358.

PMID: 38236394 DOI: 10.1007/s00216-024-05143-w.

Interlaboratory comparison of 25-hydroxyvitamin D assays: Vitamin D Standardization Program (VDSP) Intercomparison Study 2 - Part 1 liquid chromatography - tandem mass spectrometry (LC-MS/MS) assays - impact of 3-epi-25-hydroxyvitamin D on assay....

Wise S, Camara J, Burdette C, Hahm G, Nalin F, Kuszak A Anal Bioanal Chem. 2021; 414(1):333-349.

PMID: 34432104 DOI: 10.1007/s00216-021-03576-1.

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