Embryonic Exposure to the Widely-used Herbicide Atrazine Disrupts Meiosis and Normal Follicle Formation in Female Mice

Overview

Journal Sci Rep

Specialty Science

Date 2017 Jun 16

PMID 28615648

Citations 9

Authors

Aurore Gely-Pernot

Souhila Saci

Pierre-Yves Kernanec

Chunxiang Hao

Frank Giton

Christine Kervarrec

Sergei Tevosian

Severine Mazaud-Guittot

Fatima Smagulova

Affiliations

Soon will be listed here.

Abstract

The widely-used herbicide atrazine (ATZ) is detected in ground and surface water in many countries. Several studies in animals have demonstrated that ATZ has endocrine-disrupting effects on male and female reproduction in many vertebrate species. In this study, we investigated the effects of ATZ exposure on meiosis, a key step in gametogenesis in mammals. The treatment was initiated before oocyte entry into meiosis, which occurs during the embryonic period in females. We found that embryonic exposure to ATZ increases the level of 8-oxo-guanine in the nucleus of meiotic cells, reflecting oxidative stress and affecting meiotic double-strand break repair, chromosome synapsis and crossover numbers. Finally, embryonic exposure to ATZ reduces the number of primordial follicles and increases the incidence of multi-oocyte follicles in adult mice. Our data demonstrate that embryonic exposure to ATZ disrupts prophase I of meiosis and affects normal follicle formation in female mice.

Citing Articles

Atrazine: cytotoxicity, oxidative stress, apoptosis, testicular effects and chemopreventive Interventions.

Abarikwu S, Ezim O, Ikeji C, Farombi E Front Toxicol. 2023; 5:1246708.

PMID: 37876981 PMC: 10590919. DOI: 10.3389/ftox.2023.1246708.

Fertility loss: negative effects of environmental toxicants on oogenesis.

Yao X, Liu W, Xie Y, Xi M, Xiao L Front Physiol. 2023; 14:1219045.

PMID: 37601637 PMC: 10436557. DOI: 10.3389/fphys.2023.1219045.

Atrazine Toxicity: The Possible Role of Natural Products for Effective Treatment.

Das S, Sakr H, Al-Huseini I, Jetti R, Al-Qasmi S, Sugavasi R Plants (Basel). 2023; 12(12).

PMID: 37375903 PMC: 10301673. DOI: 10.3390/plants12122278.

Aged before Their Time: Atrazine and Diminished Egg Quality in Mice.

Schmidt S Environ Health Perspect. 2022; 130(12):124001.

PMID: 36520536 PMC: 9754090. DOI: 10.1289/EHP12367.

Oocyte Development and Quality in Young and Old Mice following Exposure to Atrazine.

Yun Y, Lee S, So C, Manhas R, Kim C, Wibowo T Environ Health Perspect. 2022; 130(11):117007.

PMID: 36367780 PMC: 9651182. DOI: 10.1289/EHP11343.

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