The IL-1Ra Gene Variable Number Tandem Repeat Variant is Associated with Susceptibility to Temporomandibular Disorders in Turkish Population

Overview

Journal J Clin Lab Anal

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
Pathology

Date 2017 Jun 15

PMID 28612927

Citations 7

Authors

Mehmet Kemal Tumer

Ayse Feyda Nursal

Akin Tekcan

Kaan Yerliyurt

Anastasia Geyko

Serbulent Yigit

Affiliations

Soon will be listed here.

Abstract

Background: Temporomandibular joint disorders (TMD) are a group of disorders involving temporomandibular joint and related structures. Interleukine-1 receptor antagonist (IL-1Ra) is an important anti-inflammatory molecule that competes with other interleukin-1 molecules. This study was designed to investigate the possible association of the IL-1Ra VNTR variant with the risk of TMD in the Turkish population.

Methods: Peripheral blood samples were collected from 100 patients with TMD (23 males, 77 females) and 110 healthy individuals (35 males, 75 females). Genotyping of IL-1Ra 86 bp VNTR variant was evaluated by gel electrophoresis after polymerase chain reaction (PCR).

Results: Our results show that there is a statistically significant difference between TMD patients and control group with respect to IL-1Ra genotype distribution and allele frequencies. 1.2, 1.4, and 4.4 genotypes were more common in patients, while 2.2 and 3.3 genotypes were rarer (P<.000). Frequency of alleles 1 and 4 was higher in patient groups (P<.000), whereas alleles 2 and 3 had a lower frequency in patients with TMD (P<.000).

Conclusions: This is the first correlation study that evaluates the association between IL-1Ra gene VNTR variant and TMD. The VNTR variant related to IL-1Ra gene showed a strong pattern of association with TMD that may have a potential impact on disease counseling and management. Larger studies with various ethnicities are needed to establish the impact of IL-1Ra VNTR variant on risk of developing TMD.

Citing Articles

Causal Relationship Between Obstructive Sleep Apnea and Temporomandibular Disorders: A Bidirectional Mendelian Randomization Analysis.

Wang Y, Wei H, Hu Y, Niu Y Nat Sci Sleep. 2024; 16:1045-1052.

PMID: 39076457 PMC: 11284133. DOI: 10.2147/NSS.S476277.

Investigating the relationship between the VNTR variant of the interleukin-1 receptor antagonist gene and coronary in-stent restenosis.

Klashami Z, Mostafavi A, Roudbordeh M, Abbasi A, Ebrahimi P, Asadi M Mol Biol Rep. 2023; 50(10):8575-8587.

PMID: 37644369 DOI: 10.1007/s11033-023-08759-w.

Potential pathological and molecular mechanisms of temporomandibular joint osteoarthritis.

Juan Z, Xing-Tong M, Xu Z, Chang-Yi L J Dent Sci. 2023; 18(3):959-971.

PMID: 37404608 PMC: 10316511. DOI: 10.1016/j.jds.2023.04.002.

Altered Plasma Proteins in Myogenous Temporomandibular Disorders.

Ernberg M, Jasim H, Wahlen K, Ghafouri B J Clin Med. 2022; 11(10).

PMID: 35628904 PMC: 9144449. DOI: 10.3390/jcm11102777.

Genetic overlap between temporomandibular disorders and primary headaches: A systematic review.

Cruz D, Monteiro F, Paco M, Vaz-Silva M, Lemos C, Alves-Ferreira M Jpn Dent Sci Rev. 2022; 58:69-88.

PMID: 35242249 PMC: 8881721. DOI: 10.1016/j.jdsr.2022.02.002.

References

Mansfield J, HOLDEN H, Tarlow J, Di Giovine F, McDowell T, Wilson A . Novel genetic association between ulcerative colitis and the anti-inflammatory cytokine interleukin-1 receptor antagonist. Gastroenterology. 1994; 106(3):637-42. DOI: 10.1016/0016-5085(94)90696-3. View

Generaal E, Vogelzangs N, Macfarlane G, Geenen R, Smit J, Penninx B . Reduced hypothalamic-pituitary-adrenal axis activity in chronic multi-site musculoskeletal pain: partly masked by depressive and anxiety disorders. BMC Musculoskelet Disord. 2014; 15:227. PMC: 4109382. DOI: 10.1186/1471-2474-15-227. View

Slade G, Diatchenko L, Bhalang K, Sigurdsson A, Fillingim R, Belfer I . Influence of psychological factors on risk of temporomandibular disorders. J Dent Res. 2007; 86(11):1120-5. DOI: 10.1177/154405910708601119. View

Tarlow J, Blakemore A, Lennard A, Solari R, Hughes H, Steinkasserer A . Polymorphism in human IL-1 receptor antagonist gene intron 2 is caused by variable numbers of an 86-bp tandem repeat. Hum Genet. 1993; 91(4):403-4. DOI: 10.1007/BF00217368. View

Manchanda P, Kumar A, Bid H, Mittal R . Interleukin-1beta and receptor antagonist (IL-1Ra) gene polymorphisms and the prediction of the risk of end-stage renal disease. Biomarkers. 2006; 11(2):164-73. DOI: 10.1080/13547500500525383. View

Sousa H, Breda E, Santos A, Catarino R, Pinto D, Canedo P . IL-1RN VNTR polymorphism as a susceptibility marker for nasopharyngeal carcinoma in Portugal. Arch Oral Biol. 2013; 58(8):1040-6. DOI: 10.1016/j.archoralbio.2013.02.004. View

McBeth J, Silman A, Gupta A, Chiu Y, Ray D, Morriss R . Moderation of psychosocial risk factors through dysfunction of the hypothalamic-pituitary-adrenal stress axis in the onset of chronic widespread musculoskeletal pain: findings of a population-based prospective cohort study. Arthritis Rheum. 2006; 56(1):360-71. DOI: 10.1002/art.22336. View

Dantzer R . Cytokine-induced sickness behavior: where do we stand?. Brain Behav Immun. 2001; 15(1):7-24. DOI: 10.1006/brbi.2000.0613. View

Jaiswal D, Trivedi S, Singh R, Dada R, Singh K . Association of the IL1RN gene VNTR polymorphism with human male infertility. PLoS One. 2012; 7(12):e51899. PMC: 3522614. DOI: 10.1371/journal.pone.0051899. View

10.

Blakemore A, Cox A, Gonzalez A, Maskil J, Hughes M, Wilson R . Interleukin-1 receptor antagonist allele (IL1RN*2) associated with nephropathy in diabetes mellitus. Hum Genet. 1996; 97(3):369-74. DOI: 10.1007/BF02185776. View

11.

Tumer M, Nursal A, Tekcan A, Yerliyurt K, Geyko A, Yigit S . The IL-1Ra gene variable number tandem repeat variant is associated with susceptibility to temporomandibular disorders in Turkish population. J Clin Lab Anal. 2017; 32(2). PMC: 6816944. DOI: 10.1002/jcla.22255. View

12.

Williams D, Clauw D . Understanding fibromyalgia: lessons from the broader pain research community. J Pain. 2009; 10(8):777-91. PMC: 2741022. DOI: 10.1016/j.jpain.2009.06.001. View

13.

Kellesarian S, Al-Kheraif A, Vohra F, Ghanem A, Malmstrom H, Romanos G . Cytokine profile in the synovial fluid of patients with temporomandibular joint disorders: A systematic review. Cytokine. 2015; 77:98-106. DOI: 10.1016/j.cyto.2015.11.005. View

14.

Singh H, Sachan R, Goel H, Mittal B . Genetic variants of interleukin-1RN and interleukin-1beta genes and risk of cervical cancer. BJOG. 2008; 115(5):633-8. DOI: 10.1111/j.1471-0528.2007.01655.x. View

15.

Turner-Cobb J, Osborn M, Silva L, Keogh E, Jessop D . Sex differences in hypothalamic-pituitary-adrenal axis function in patients with chronic pain syndrome. Stress. 2010; 13(4):292-300. DOI: 10.3109/10253890903524785. View

16.

Gur A, Karakoc M, Nas K, Remzi , Cevik , Denli A . Cytokines and depression in cases with fibromyalgia. J Rheumatol. 2002; 29(2):358-61. View

17.

Lagha A, Zidi S, Stayoussef M, Gazouani E, Kochkar R, Kochbati S . Interleukin-1β, Interleukin1-Ra, Interleukin-10, and tumor necrosis factor-α polymorphisms in Tunisian patients with rheumatoid arthritis. Pathol Biol (Paris). 2015; 63(4-5):179-84. DOI: 10.1016/j.patbio.2015.04.004. View

18.

Afari N, Ahumada S, Wright L, Mostoufi S, Golnari G, Reis V . Psychological trauma and functional somatic syndromes: a systematic review and meta-analysis. Psychosom Med. 2013; 76(1):2-11. PMC: 3894419. DOI: 10.1097/PSY.0000000000000010. View

19.

Strandberg L, Lorentzon M, Hellqvist A, Nilsson S, Wallenius V, Ohlsson C . Interleukin-1 system gene polymorphisms are associated with fat mass in young men. J Clin Endocrinol Metab. 2006; 91(7):2749-54. DOI: 10.1210/jc.2005-2786. View

20.

Nilsson I . Reliability, validity, incidence and impact of temporormandibular pain disorders in adolescents. Swed Dent J Suppl. 2007; (183):7-86. View