Treadmill Exercise Alters Ecstasy- Induced Long- Term Potentiation Disruption in the Hippocampus of Male Rats

Overview

Journal Metab Brain Dis

Publisher Springer

Specialties Endocrinology
Neurology

Date 2017 Jun 15

PMID 28612273

Citations 3

Authors

Azam Sajadi

Iraj Amiri

Alireza Gharebaghi

Alireza Komaki

Masoumeh Asadbegi

Siamak Shahidi

Mehdi Mehdizadeh

Sara Soleimani Asl

Affiliations

Soon will be listed here.

Abstract

3, 4-methylenedioxymethamphetamine (MDMA) or ecstasy is a derivative of amphetamine that leads to long term potentiation (LTP) disruption in the hippocampal dentate gyrus (DG). Exercise has been accepted as a treatment for the improvement of neurodegenerative disease. Herein, the effects of exercise on the MDMA- induced neurotoxicity were assessed. Male Wistar rats received intraperitoneal injection of MDMA (10 mg/kg) and exercised for one month on a treadmill (Simultaneously or asynchronously with MDMA). LTP and expression of BDNF were assessed using electrophysiology and western blotting methods, respectively. MDMA attenuated the field excitatory post-synaptic potential (fEPSP) slope in comparison with the control group, whereas treadmill exercise increased this parameter when compared to MDMA group. Furthermore, BDNF expression significantly decreased in MDMA group and treadmill exercise could increase that. In conclusion, results of this study suggest that synchronous exercise is able to improve MDMA-induced LTP changes through increase of BDNF expression in the hippocampus of rats.

Citing Articles

Aromatic Bromination Abolishes Deficits in Visuospatial Learning Induced by MDMA ("Ecstasy") in Rats While Preserving the Ability to Increase LTP in the Prefrontal Cortex.

Saez-Briones P, Palma B, Burgos H, Barra R, Hernandez A Int J Mol Sci. 2023; 24(4).

PMID: 36835133 PMC: 9963799. DOI: 10.3390/ijms24043724.

Exercise Prevents Memory Consolidation Defects Via Enhancing Prolactin Responsiveness of CA1 Neurons in Mice Under Chronic Stress.

Leem Y, Park J, Chang H, Park J, Kim H Mol Neurobiol. 2019; 56(9):6609-6625.

PMID: 30905005 DOI: 10.1007/s12035-019-1560-z.

3,4-methylenedioxymethamphetamine (MDMA) impairs the extinction and reconsolidation of fear memory in rats.

Hake H, Davis J, Wood R, Tanner M, Loetz E, Sanchez A Physiol Behav. 2018; 199:343-350.

PMID: 30529341 PMC: 6557441. DOI: 10.1016/j.physbeh.2018.12.007.

References

van Praag H, Shubert T, Zhao C, Gage F . Exercise enhances learning and hippocampal neurogenesis in aged mice. J Neurosci. 2005; 25(38):8680-5. PMC: 1360197. DOI: 10.1523/JNEUROSCI.1731-05.2005. View

MAZER C, Muneyyirci J, Taheny K, Raio N, BORELLA A . Serotonin depletion during synaptogenesis leads to decreased synaptic density and learning deficits in the adult rat: a possible model of neurodevelopmental disorders with cognitive deficits. Brain Res. 1997; 760(1-2):68-73. DOI: 10.1016/s0006-8993(97)00297-7. View

Kuipers S, Trentani A, Tiron A, Mao X, Kuhl D, Bramham C . BDNF-induced LTP is associated with rapid Arc/Arg3.1-dependent enhancement in adult hippocampal neurogenesis. Sci Rep. 2016; 6:21222. PMC: 4758047. DOI: 10.1038/srep21222. View

Reisi P, Babri S, Alaei H, Sharifi M, Mohaddes G, Noorbakhsh S . Treadmill running improves long-term potentiation (LTP) defects in streptozotocin-induced diabetes at dentate gyrus in rats. Pathophysiology. 2009; 17(1):33-8. DOI: 10.1016/j.pathophys.2009.06.001. View

Zargooshnia S, Shahidi S, Ghahremanitamadon F, Nikkhah A, Mehdizadeh M, Asl S . The protective effect of Borago Officinalis extract on amyloid β (25-35)-induced long term potentiation disruption in the dentate gyrus of male rats. Metab Brain Dis. 2014; 30(1):151-6. DOI: 10.1007/s11011-014-9594-4. View

Lu B, Nagappan G, Lu Y . BDNF and synaptic plasticity, cognitive function, and dysfunction. Handb Exp Pharmacol. 2014; 220:223-50. DOI: 10.1007/978-3-642-45106-5_9. View

Radak Z, Toldy A, Szabo Z, Siamilis S, Nyakas C, Silye G . The effects of training and detraining on memory, neurotrophins and oxidative stress markers in rat brain. Neurochem Int. 2006; 49(4):387-92. DOI: 10.1016/j.neuint.2006.02.004. View

Fernandez S, Muzerelle A, Scotto-Lomassese S, Barik J, Gruart A, Delgado-Garcia J . Constitutive and Acquired Serotonin Deficiency Alters Memory and Hippocampal Synaptic Plasticity. Neuropsychopharmacology. 2016; 42(2):512-523. PMC: 5399229. DOI: 10.1038/npp.2016.134. View

Griesbach G, Hovda D, Molteni R, Wu A, Gomez-Pinilla F . Voluntary exercise following traumatic brain injury: brain-derived neurotrophic factor upregulation and recovery of function. Neuroscience. 2004; 125(1):129-39. DOI: 10.1016/j.neuroscience.2004.01.030. View

10.

Kovalchuk Y, Hanse E, Kafitz K, Konnerth A . Postsynaptic Induction of BDNF-Mediated Long-Term Potentiation. Science. 2002; 295(5560):1729-34. DOI: 10.1126/science.1067766. View

11.

Alomari M, Khabour O, Alzoubi K, Alzubi M . Combining restricted diet with forced or voluntary exercises improves hippocampal BDNF and cognitive function in rats. Int J Neurosci. 2015; 126(4):366-73. DOI: 10.3109/00207454.2015.1012587. View

12.

Mirzamohammadi S, Aali E, Najafi R, Kamarul T, Mehrabani M, Aminzadeh A . Effect of 17β-estradiol on mediators involved in mesenchymal stromal cell trafficking in cell therapy of diabetes. Cytotherapy. 2014; 17(1):46-57. DOI: 10.1016/j.jcyt.2014.06.009. View

13.

Rauskolb S, Zagrebelsky M, Dreznjak A, Deogracias R, Matsumoto T, Wiese S . Global deprivation of brain-derived neurotrophic factor in the CNS reveals an area-specific requirement for dendritic growth. J Neurosci. 2010; 30(5):1739-49. PMC: 6633992. DOI: 10.1523/JNEUROSCI.5100-09.2010. View

14.

Morris R, Garrud P, Rawlins J, Okeefe J . Place navigation impaired in rats with hippocampal lesions. Nature. 1982; 297(5868):681-3. DOI: 10.1038/297681a0. View

15.

Ferreira T, Lo Iacono L, Gross C . Serotonin receptor 1A modulates actin dynamics and restricts dendritic growth in hippocampal neurons. Eur J Neurosci. 2010; 32(1):18-26. DOI: 10.1111/j.1460-9568.2010.07283.x. View

16.

Parrott A . Recreational Ecstasy/MDMA, the serotonin syndrome, and serotonergic neurotoxicity. Pharmacol Biochem Behav. 2002; 71(4):837-44. DOI: 10.1016/s0091-3057(01)00711-0. View

17.

Tong L, Shen H, Perreau V, Balazs R, Cotman C . Effects of exercise on gene-expression profile in the rat hippocampus. Neurobiol Dis. 2001; 8(6):1046-56. DOI: 10.1006/nbdi.2001.0427. View

18.

Grider M, Mamounas L, Le W, Shine H . In situ expression of brain-derived neurotrophic factor or neurotrophin-3 promotes sprouting of cortical serotonergic axons following a neurotoxic lesion. J Neurosci Res. 2005; 82(3):404-12. DOI: 10.1002/jnr.20635. View

19.

Arias-Cavieres A, Rozas C, Reyes-Parada M, Barrera N, Pancetti F, Loyola S . MDMA ("ecstasy") impairs learning in the Morris Water Maze and reduces hippocampal LTP in young rats. Neurosci Lett. 2009; 469(3):375-9. DOI: 10.1016/j.neulet.2009.12.031. View

20.

Paxinos G, Watson C, Pennisi M, Topple A . Bregma, lambda and the interaural midpoint in stereotaxic surgery with rats of different sex, strain and weight. J Neurosci Methods. 1985; 13(2):139-43. DOI: 10.1016/0165-0270(85)90026-3. View