Effects of Resveratrol, Curcumin, Berberine and Other Nutraceuticals on Aging, Cancer Development, Cancer Stem Cells and MicroRNAs

Overview

Journal Aging (Albany NY)

Specialty Geriatrics

Date 2017 Jun 15

PMID 28611316

Citations 92

Authors

James A McCubrey

Kvin Lertpiriyapong

Linda S Steelman

Steve L Abrams

Li V Yang

Ramiro M Murata

Pedro L Rosalen

Aurora Scalisi

Luca M Neri

Lucio Cocco

Stefano Ratti

Alberto M Martelli

Piotr Laidler

Joanna Dulinska-Litewka

Dariusz Rakus

Agnieszka Gizak

Paolo Lombardi

Ferdinando Nicoletti

Saverio Candido

Massimo Libra

Giuseppe Montalto

Melchiorre Cervello

Affiliations

Soon will be listed here.

Abstract

Natural products or nutraceuticals have been shown to elicit anti-aging, anti-cancer and other health-enhancing effects. A key target of the effects of natural products may be the regulation of microRNA (miR) expression which results in cell death or prevents aging, diabetes, cardiovascular and other diseases. This review will focus on a few natural products, especially on resveratrol (RES), curcumin (CUR) and berberine (BBR). RES is obtained from the skins of grapes and other fruits and berries. RES may extend human lifespan by activating the sirtuins and SIRT1 molecules. CUR is isolated from the root of turmeric (). CUR is currently used in the treatment of many disorders, especially in those involving an inflammatory process. CUR and modified derivatives have been shown to have potent anti-cancer effects, especially on cancer stem cells (CSC). BBR is also isolated from various plants () and has been used for centuries in traditional medicine to treat diseases such as adult- onset diabetes. Understanding the benefits of these and other nutraceuticals may result in approaches to improve human health.

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