Protective Effects of Amniotic Fluid in the Setting of Necrotizing Enterocolitis

Overview

Journal Pediatr Res

Specialties Biology
Pediatrics

Date 2017 Jun 14

PMID 28609432

Citations 14

Authors

Soham Dasgupta

Sunil Kumar Jain

Affiliations

Soon will be listed here.

Abstract

Necrotizing enterocolitis (NEC) is the most common life threatening condition affecting preterm infants. NEC occurs in 1-5% of all neonatal intensive care admissions and 5-10% of very low birth weight infants. The protective role of human breast milk (BM) has been well established. It has also been shown that amniotic fluid (AF) and BM have many similarities in terms of presence of growth and other immune-modulatory factors. This finding led to the initial hypothesis that AF may exert similar protective effects against the development of NEC, as does BM. Multiple studies have elucidated the presence of growth factors in AF and the protective effect of AF against NEC. Studies have also described possible mechanisms how AF protects against NEC. At present, research in this particular area is extremely active and robust. This review summarizes the various studies looking at the protective effects of AF against the development of NEC. It also provides an insight into future directions, the vast potential of AF as a readily available biologic medium, and the ethical barriers that must be overcome before using AF.

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References

Lemyre B, Xiu W, Rouvinez Bouali N, Brintnell J, Janigan J, Suh K . A decrease in the number of cases of necrotizing enterocolitis associated with the enhancement of infection prevention and control measures during a Staphylococcus aureus outbreak in a neonatal intensive care unit. Infect Control Hosp Epidemiol. 2011; 33(1):29-33. DOI: 10.1086/663343. View

Christensen R, Havranek T, Gerstmann D, Calhoun D . Enteral administration of a simulated amniotic fluid to very low birth weight neonates. J Perinatol. 2005; 25(6):380-5. DOI: 10.1038/sj.jp.7211306. View

Lucas A, Cole T . Breast milk and neonatal necrotising enterocolitis. Lancet. 1990; 336(8730):1519-23. DOI: 10.1016/0140-6736(90)93304-8. View

Barmeyer C, Horak I, Zeitz M, Fromm M, Schulzke J . The interleukin-2-deficient mouse model. Pathobiology. 2003; 70(3):139-42. DOI: 10.1159/000068145. View

Palsson-McDermott E, ONeill L . Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4. Immunology. 2004; 113(2):153-62. PMC: 1782563. DOI: 10.1111/j.1365-2567.2004.01976.x. View

Good M, Sodhi C, Hackam D . Evidence-based feeding strategies before and after the development of necrotizing enterocolitis. Expert Rev Clin Immunol. 2014; 10(7):875-84. PMC: 4113601. DOI: 10.1586/1744666X.2014.913481. View

Feng J, Besner G . Heparin-binding epidermal growth factor-like growth factor promotes enterocyte migration and proliferation in neonatal rats with necrotizing enterocolitis. J Pediatr Surg. 2007; 42(1):214-20. DOI: 10.1016/j.jpedsurg.2006.09.055. View

Kaviani A, Perry T, Dzakovic A, Jennings R, ZIEGLER M, Fauza D . The amniotic fluid as a source of cells for fetal tissue engineering. J Pediatr Surg. 2001; 36(11):1662-5. DOI: 10.1053/jpsu.2001.27945. View

Brace R . Physiology of amniotic fluid volume regulation. Clin Obstet Gynecol. 1997; 40(2):280-9. DOI: 10.1097/00003081-199706000-00005. View

10.

Welniak L, Khaled A, Anver M, Komschlies K, Wiltrout R, Durum S . Gastrointestinal cells of IL-7 receptor null mice exhibit increased sensitivity to irradiation. J Immunol. 2001; 166(5):2924-8. DOI: 10.4049/jimmunol.166.5.2923. View

11.

Lin P, Stoll B . Necrotising enterocolitis. Lancet. 2006; 368(9543):1271-83. DOI: 10.1016/S0140-6736(06)69525-1. View

12.

Arboleya S, Ang L, Margolles A, Yiyuan L, Dongya Z, Liang X . Deep 16S rRNA metagenomics and quantitative PCR analyses of the premature infant fecal microbiota. Anaerobe. 2012; 18(3):378-80. DOI: 10.1016/j.anaerobe.2012.04.013. View

13.

Commare C, Tappenden K . Development of the infant intestine: implications for nutrition support. Nutr Clin Pract. 2007; 22(2):159-73. DOI: 10.1177/0115426507022002159. View

14.

Clark J, Lane R, MacLennan N, Holubec H, Dvorakova K, Halpern M . Epidermal growth factor reduces intestinal apoptosis in an experimental model of necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2004; 288(4):G755-62. DOI: 10.1152/ajpgi.00172.2004. View

15.

Claud E, Savidge T, Walker W . Modulation of human intestinal epithelial cell IL-8 secretion by human milk factors. Pediatr Res. 2003; 53(3):419-25. DOI: 10.1203/01.PDR.0000050141.73528.AD. View

16.

Chan K, Ho J, Chan K, Tam P . A study of gut immunity to enteral endotoxin in rats of different ages: a possible cause for necrotizing enterocolitis. J Pediatr Surg. 2002; 37(10):1435-40. DOI: 10.1053/jpsu.2002.35407. View

17.

Jantscher-Krenn E, Zherebtsov M, Nissan C, Goth K, Guner Y, Naidu N . The human milk oligosaccharide disialyllacto-N-tetraose prevents necrotising enterocolitis in neonatal rats. Gut. 2011; 61(10):1417-25. PMC: 3909680. DOI: 10.1136/gutjnl-2011-301404. View

18.

Hirai C, Ichiba H, Saito M, Shintaku H, Yamano T, Kusuda S . Trophic effect of multiple growth factors in amniotic fluid or human milk on cultured human fetal small intestinal cells. J Pediatr Gastroenterol Nutr. 2002; 34(5):524-8. DOI: 10.1097/00005176-200205000-00010. View

19.

Hackam D, Upperman J, Grishin A, Ford H . Disordered enterocyte signaling and intestinal barrier dysfunction in the pathogenesis of necrotizing enterocolitis. Semin Pediatr Surg. 2005; 14(1):49-57. DOI: 10.1053/j.sempedsurg.2004.10.025. View

20.

Juul S, Ledbetter D, JOYCE A, Dame C, Christensen R, Zhao Y . Erythropoietin acts as a trophic factor in neonatal rat intestine. Gut. 2001; 49(2):182-9. PMC: 1728399. DOI: 10.1136/gut.49.2.182. View