Graft Predominance After Double Umbilical Cord Blood Transplantation: a Review

Overview

Journal Stem Cell Investig

Publisher AME Publishing Company

Date 2017 Jun 14

PMID 28607921

Citations 2

Authors

Jan J Cornelissen

Burak Kalin

Cor H J Lamers

Affiliations

Soon will be listed here.

Abstract

Several parameters are involved in graft predominance after double umbilical cord blood transplantation (dUCBT), of which T-cell alloreactivity between the grafts is now considered to be the major denominator. We recently showed that alloreactive CD4+ T-cells originating from the predominant CBU recognize HLA-class II allele mismatches and can readily be detected in the majority of patients. In addition, it was shown that HLA-class II allele-specific CD4+ T-cells were able to recognize primary leukemic cells when the mismatched HLA-class II allele was shared between the rejected CBU and the patient. These results further underscored the role of alloreactive T-cells, notably class II specific CD4+ T-cells, in graft-versus-graft reactions and in graft-versus-leukemia after dUCBT.

Citing Articles

Impact of allele-level HLA matching on outcomes after double cord blood transplantation in adults with malignancies.

Fatobene G, Mariano L, Volt F, Moreira F, Conelissen J, Furst S Blood Adv. 2023; 7(13):3297-3306.

PMID: 36877784 PMC: 10336258. DOI: 10.1182/bloodadvances.2022009251.

Primary graft failure, but not relapse, may be identified by early chimerism following double cord blood unit transplantation.

Hough R, Lopes A, Patrick P, Russell N, Raj K, Tholouli E Blood Adv. 2021; 6(7):2414-2426.

PMID: 34700343 PMC: 9006284. DOI: 10.1182/bloodadvances.2021005106.

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