Synthesis and Evaluation of Curcuminoid Analogues As Antioxidant and Antibacterial Agents

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2017 Jun 13

PMID 28604614

Citations 3

Authors

Dalia R Emam

Ahmad M Alhajoj

Khaled M Elattar

Nabila A Kheder

Ahmed A Fadda

Affiliations

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Abstract

Diazocoupling reaction of curcumin with different diazonium salts of -toluidine, 2-aminopyridine, and 4-aminoantipyrine in pyridine yielded the arylhydrazones -. Arylhydrazone of -toluidine reacted with urea, thiourea, and guanidine nitrate to produce 5,6-dihydropyrimidines. Further reaction of with 2,3-diaminopyrdine in sodium ethoxide solution yielded 1-pyrido[2,3-][1,4]diazepine derivative. (2,5-dihydroisoxazole) is obtained from the reaction of with hydroxylamine hydrochloride, while its reactions with hydrazines afforded the respective 4,5-dihydro-1-pyrazoles. The target compounds were evaluated as antioxidant and antibacterial agents. The tested compounds showed good to moderate activities compared to ascorbic acid and chloramphenicol, respectively.

Citing Articles

Ultrasonic-Assisted Synthesis of Heterocyclic Curcumin Analogs as Antidiabetic, Antibacterial, and Antioxidant Agents Combined with in vitro and in silico Studies.

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Eco-Friendly Synthesis, Characterization and Biological Evaluation of Some Novel Pyrazolines Containing Thiazole Moiety as Potential Anticancer and Antimicrobial Agents.

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Dong F, Li L, Lin L, He D, Chen J, Wei W Molecules. 2017; 22(9).

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