» Articles » PMID: 27956904

Antibacterial Action of Curcumin Against : A Brief Review

Overview
Journal J Trop Med
Publisher Wiley
Specialty Tropical Medicine
Date 2016 Dec 14
PMID 27956904
Citations 68
Authors
Affiliations
Soon will be listed here.
Abstract

Curcumin, the major constituent of L. (Zingiberaceae family) or turmeric, commonly used for cooking in Asian cuisine, is known to possess a broad range of pharmacological properties at relatively nontoxic doses. Curcumin is found to be effective against (). As demonstrated by experiment, curcumin exerts even more potent effects when used in combination with various other antibacterial agents. Hence, curcumin which is a natural product derived from plant is believed to have profound medicinal benefits and could be potentially developed into a naturally derived antibiotic in the future. However, there are several noteworthy challenges in the development of curcumin as a medicine. infections, particularly those caused by the multidrug-resistant strains, have emerged as a global health issue and urgent action is needed. This review focuses on the antibacterial activities of curcumin against both methicillin-sensitive (MSSA) and methicillin-resistant (MRSA). We also attempt to highlight the potential challenges in the effort of developing curcumin into a therapeutic antibacterial agent.

Citing Articles

Evaluation of hydrogel loading with curcumin and silver nanoparticles: biocompatibilities and anti-biofilm activities.

Hong W, Lee W, Musa S, Kamaruzaman N, Loo C Biometals. 2025; .

PMID: 39979667 DOI: 10.1007/s10534-025-00670-0.


Bioactive Silk Revolution: Harnessing Curcuminoid Dye and Chitosan for Superior Antimicrobial Defence and UV Shielding.

Do K, Ahsan T, Wahab A, Tayyab M, Yin X, Pan N Pharmaceutics. 2025; 16(12.

PMID: 39771490 PMC: 11728638. DOI: 10.3390/pharmaceutics16121510.


The Dynamic Role of Curcumin in Mitigating Human Illnesses: Recent Advances in Therapeutic Applications.

Alam M, Jamir Anwar M, Maity M, Azam F, Jaremko M, Emwas A Pharmaceuticals (Basel). 2025; 17(12.

PMID: 39770516 PMC: 11679877. DOI: 10.3390/ph17121674.


Exploring the Interaction of Lipid Bilayers with Curcumin-Laponite Nanoparticles: Implications for Drug Delivery and Therapeutic Applications.

Pawar N, Pena-Figueroa M, Verde-Sesto E, Maestro A, Alvarez-Fernandez A Small. 2024; 20(52):e2406885.

PMID: 39466993 PMC: 11673403. DOI: 10.1002/smll.202406885.


Effect of curcumin on physico-mechanical properties of heat polymerized denture base resin.

Mahajan A, Chander N, Balasubramanian M BMC Oral Health. 2024; 24(1):1300.

PMID: 39462349 PMC: 11514879. DOI: 10.1186/s12903-024-05086-9.


References
1.
Thapliyal R, Maru G . Inhibition of cytochrome P450 isozymes by curcumins in vitro and in vivo. Food Chem Toxicol. 2001; 39(6):541-7. DOI: 10.1016/s0278-6915(00)00165-4. View

2.
Zhao W, Hu Z, Okubo S, Hara Y, Shimamura T . Mechanism of synergy between epigallocatechin gallate and beta-lactams against methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2001; 45(6):1737-42. PMC: 90539. DOI: 10.1128/AAC.45.6.1737-1742.2001. View

3.
Akiyama H, Fujii K, Yamasaki O, Oono T, Iwatsuki K . Antibacterial action of several tannins against Staphylococcus aureus. J Antimicrob Chemother. 2001; 48(4):487-91. DOI: 10.1093/jac/48.4.487. View

4.
. NTP Toxicology and Carcinogenesis Studies of Turmeric Oleoresin (CAS No. 8024-37-1) (Major Component 79%-85% Curcumin, CAS No. 458-37-7) in F344/N Rats and B6C3F1 Mice (Feed Studies). Natl Toxicol Program Tech Rep Ser. 1993; 427:1-275. View

5.
Chainani-Wu N . Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa). J Altern Complement Med. 2003; 9(1):161-8. DOI: 10.1089/107555303321223035. View