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Synergistic Activity of Ceftazidime-avibactam and Aztreonam Against Serine and Metallo-β-lactamase-producing Gram-negative Pathogens

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Date 2017 Jun 13
PMID 28602518
Citations 39
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Abstract

This study assessed the in vitro synergy between ceftazidime, aztreonam, and ceftazidime-avibactam against serine and metallo-β-lactamase (MBL)-producing pathogens via the Etest MIC:MIC ratio and Agar-Etest synergy methods. The combination of aztreonam and ceftazidime-avibactam was synergistic against all Enterobacteriaceae. None of the tested combinations were consistently synergistic against IMP-producing P. aeruginosa.

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