Pediatric Non-Alcoholic Fatty Liver Disease

Overview

Journal Children (Basel)

Specialty Health Services

Date 2017 Jun 10

PMID 28598410

Citations 34

Authors

Haley Bush

Pegah Golabi

Zobair M Younossi

Affiliations

Soon will be listed here.

Abstract

With the increase in the prevalence of obesity, non-alcoholic fatty liver disease (NAFLD) has become among the leading causes of chronic liver disease in the pediatric age group. Once believed to be a "two-hit process", it is now clear that the actual pathophysiology of NAFLD is complex and involves multiple pathways. Moreover, NAFLD is not always benign, and patients with non-alcoholic steatohepatitis (NASH) are at increased risk of developing advanced stages of liver disease. It has also been shown that NAFLD is not only a liver disease, but is also associated with multiple extrahepatic manifestations, including cardiovascular diseases, type 2 diabetes, and low bone mineral density. Although the data is scarce in the pediatric population, some studies have suggested that long-term mortality and the requirement of liver transplantation will continue to increase in patients with NAFLD. More studies are needed to better understand the natural history of NAFLD, especially in the pediatric age group.

Citing Articles

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Dietary and lifestyle indices for hyperinsulinemia and odds of MAFLD in overweight and obese children and adolescents.

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The association between dietary intake of branched-chain amino acids and the odds of nonalcoholic fatty liver disease among overweight and obese children and adolescents.

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A significant and persistent rise in the global burden of adolescent NAFLD and NASH estimated by BMI.

Lin X, Li J, Huang L, Lin L, Hong M, Weng S Front Public Health. 2024; 12:1437432.

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The effects of weight loss interventions on children and adolescents with non-alcoholic fatty liver disease: A systematic review and meta-analysis.

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