Standardization of I--iodobenzylguanidine Myocardial Sympathetic Activity Imaging: Phantom Calibration and Clinical Applications

Overview

Journal Clin Transl Imaging

Publisher Springer

Date 2017 Jun 10

PMID 28596948

Citations 15

Authors

Kenichi Nakajima

Derk O Verschure

Koichi Okuda

Hein J Verberne

Affiliations

Soon will be listed here.

Abstract

Purpose: Myocardial sympathetic imaging with I--iodobenzylguanidine (I-IBG) has gained clinical momentum. Although the need for standardization of I-IBG myocardial uptake has been recognized, the availability of practical clinical standardization approaches is limited. The need for standardization includes the heart-to-mediastinum ratio (HMR) and washout rate with planar imaging, and myocardial defect scoring with single-photon emission computed tomography (SPECT).

Methods: The planar HMR shows considerable variation due to differences in collimator design. These camera-collimator differences can be overcome by cross-calibration phantom experiments. The principles of these cross-calibration phantom experiments are summarized in this article. I-IBG SPECT databases were compiled by Japanese Society of Nuclear Medicine working group. Literature was searched based on the words "I-IBG quantification method", "standardization", "heart-to-mediastinum ratio", and its application to "risk model".

Results: Calibration phantom experiments have been successfully performed in Japan and Europe. The benefit of these cross-calibration phantom experiments is that variation in the HMR between institutions is minimized including low-energy, low-medium-energy and medium-energy collimators. The use of myocardial I-IBG SPECT can be standardized using I-IBG normal databases as a basis for quantitative evaluation. This standardization method can be applied in cardiac event prediction models.

Conclusion: Standardization of myocardial I-IBG outcome parameters may facilitate a universal implementation of myocardial I-IBG scintigraphy.

Citing Articles

Comparison of Taiwanese and European Calibration Factors for Heart-to-Mediastinum Ratio in Multicenter I-mIBG Phantom Studies.

Okuda K, Nakajima K, Hung G, Wu H, Verschure D, Verberne H Ann Nucl Cardiol. 2023; 9(1):54-60.

PMID: 38058572 PMC: 10696153. DOI: 10.17996/anc.23-00006.

Cardiac sympathetic activity and relationship to cardiac events and left ventricular reverse remodeling in patients with non-ischemic dilated cardiomyopathy.

Mizutani T, Morimoto R, Isobe S, Ito R, Araki T, Kimura Y Ann Nucl Med. 2023; 37(8):451-461.

PMID: 37273093 DOI: 10.1007/s12149-023-01838-9.

Machine learning-based prediction of conversion coefficients for I-123 metaiodobenzylguanidine heart-to-mediastinum ratio.

Okuda K, Nakajima K, Kitamura C, Ljungberg M, Hosoya T, Kirihara Y J Nucl Cardiol. 2023; 30(4):1630-1641.

PMID: 36740650 PMC: 10372132. DOI: 10.1007/s12350-023-03198-3.

Autonomic nervous system activity in primary Raynaud's phenomenon: Heart rate variability, plasma catecholamines and [ I]MIBG heart scintigraphy.

Lindberg L, Brinth L, Bergmann M, Kristensen B, Hansen T, Hasbak P Clin Physiol Funct Imaging. 2021; 42(2):104-113.

PMID: 34972251 PMC: 9303416. DOI: 10.1111/cpf.12737.

Impaired Cardiac Sympathetic Innervation Increases the Risk of Cardiac Events in Heart Failure Patients with Left Ventricular Hypertrophy and Mechanical Dyssynchrony.

Doi T, Nakata T, Noto T, Mita T, Nagahara D, Yuda S J Clin Med. 2021; 10(21).

PMID: 34768566 PMC: 8584654. DOI: 10.3390/jcm10215047.

References

Nakajima K, Matsubara K, Ishikawa T, Motomura N, Maeda R, Akhter N . Correction of iodine-123-labeled meta-iodobenzylguanidine uptake with multi-window methods for standardization of the heart-to-mediastinum ratio. J Nucl Cardiol. 2007; 14(6):843-51. DOI: 10.1016/j.nuclcard.2007.08.002. View

Travin M, Henzlova M, van Eck-Smit B, Jain D, Carrio I, Folks R . Assessment of I-mIBG and Tc-tetrofosmin single-photon emission computed tomographic images for the prediction of arrhythmic events in patients with ischemic heart failure: Intermediate severity innervation defects are associated with higher.... J Nucl Cardiol. 2016; 24(2):377-391. DOI: 10.1007/s12350-015-0336-8. View

Verschure D, Poel E, Nakajima K, Okuda K, van Eck-Smit B, Somsen G . A European myocardial I-mIBG cross-calibration phantom study. J Nucl Cardiol. 2017; 25(4):1191-1197. PMC: 6133137. DOI: 10.1007/s12350-017-0782-6. View

Chen J, Garcia E, Galt J, Folks R, Carrio I . Improved quantification in 123I cardiac SPECT imaging with deconvolution of septal penetration. Nucl Med Commun. 2006; 27(7):551-8. DOI: 10.1097/00006231-200607000-00002. View

Inoue Y, Abe Y, Itoh Y, Asano Y, Kikuchi K, Sakamoto Y . Acquisition protocols and correction methods for estimation of the heart-to-mediastinum ratio in 123I-metaiodobenzylguanidine cardiac sympathetic imaging. J Nucl Med. 2013; 54(5):707-13. DOI: 10.2967/jnumed.112.111955. View

Verschure D, Bongers V, Hagen P, Somsen G, van Eck-Smit B, Verberne H . Impact of a predefined mediastinal ROI on inter-observer variability of planar ¹²³I-MIBG heart-to-mediastinum ratio. J Nucl Cardiol. 2014; 21(3):605-13. DOI: 10.1007/s12350-014-9854-z. View

Yamashina S, Yamazaki J . Role of MIBG myocardial scintigraphy in the assessment of heart failure: the need to establish evidence. Eur J Nucl Med Mol Imaging. 2004; 31(10):1353-5. DOI: 10.1007/s00259-004-1493-1. View

Zhou Y, Zhou W, Folks R, Manatunga D, Jacobson A, Bax J . I-123 mIBG and Tc-99m myocardial SPECT imaging to predict inducibility of ventricular arrhythmia on electrophysiology testing: a retrospective analysis. J Nucl Cardiol. 2014; 21(5):913-20. DOI: 10.1007/s12350-014-9911-7. View

Agostini D, Verberne H, Burchert W, Knuuti J, Povinec P, Sambuceti G . I-123-mIBG myocardial imaging for assessment of risk for a major cardiac event in heart failure patients: insights from a retrospective European multicenter study. Eur J Nucl Med Mol Imaging. 2007; 35(3):535-46. DOI: 10.1007/s00259-007-0639-3. View

10.

Chen J, Folks R, Verdes L, Manatunga D, Jacobson A, Garcia E . Quantitative I-123 mIBG SPECT in differentiating abnormal and normal mIBG myocardial uptake. J Nucl Cardiol. 2011; 19(1):92-9. DOI: 10.1007/s12350-011-9438-0. View

11.

Chen W, Cao Q, Dilsizian V . Variation of heart-to-mediastinal ratio in (123)I-mIBG cardiac sympathetic imaging: its affecting factors and potential corrections. Curr Cardiol Rep. 2011; 13(2):132-7. DOI: 10.1007/s11886-010-0157-y. View

12.

Verschure D, Veltman C, Manrique A, Somsen G, Koutelou M, Katsikis A . For what endpoint does myocardial 123I-MIBG scintigraphy have the greatest prognostic value in patients with chronic heart failure? Results of a pooled individual patient data meta-analysis. Eur Heart J Cardiovasc Imaging. 2014; 15(9):996-1003. DOI: 10.1093/ehjci/jeu044. View

13.

Soman P, Travin M, Gerson M, Cullom S, Thompson R . I-123 MIBG Cardiac Imaging. J Nucl Cardiol. 2015; 22(4):677-85. DOI: 10.1007/s12350-015-0108-5. View

14.

Dimitriu-Leen A, Gimelli A, Al Younis I, Veltman C, Verberne H, Wolterbeek R . The impact of acquisition time of planar cardiac (123)I-MIBG imaging on the late heart to mediastinum ratio. Eur J Nucl Med Mol Imaging. 2015; 43(2):326-332. PMC: 4700092. DOI: 10.1007/s00259-015-3220-5. View

15.

Nakajima K . Normal values for nuclear cardiology: Japanese databases for myocardial perfusion, fatty acid and sympathetic imaging and left ventricular function. Ann Nucl Med. 2010; 24(3):125-35. PMC: 2855806. DOI: 10.1007/s12149-009-0337-2. View

16.

Bui A, Horwich T, Fonarow G . Epidemiology and risk profile of heart failure. Nat Rev Cardiol. 2010; 8(1):30-41. PMC: 3033496. DOI: 10.1038/nrcardio.2010.165. View

17.

Motomura N, Ichihara T, Takayama T, Aoki S, Kubo H, Takeda K . [Practical compensation method of downscattered component due to high energy photon in 123I imaging]. Kaku Igaku. 2000; 36(9):997-1005. View

18.

Nakajima K, Nakata T . Cardiac 123I-MIBG Imaging for Clinical Decision Making: 22-Year Experience in Japan. J Nucl Med. 2015; 56 Suppl 4:11S-19S. DOI: 10.2967/jnumed.114.142794. View

19.

Verschure D, Lutter R, van Eck-Smit B, Somsen G, Verberne H . Myocardial I-mIBG scintigraphy in relation to markers of inflammation and long-term clinical outcome in patients with stable chronic heart failure. J Nucl Cardiol. 2016; 25(3):845-853. PMC: 5966475. DOI: 10.1007/s12350-016-0697-7. View

20.

Nakajima K, Matsumoto N, Kasai T, Matsuo S, Kiso K, Okuda K . Normal values and standardization of parameters in nuclear cardiology: Japanese Society of Nuclear Medicine working group database. Ann Nucl Med. 2016; 30(3):188-99. PMC: 4819542. DOI: 10.1007/s12149-016-1065-z. View