Nuclear Factor I/B: A Master Regulator of Cell Differentiation with Paradoxical Roles in Cancer

Overview

Journal EBioMedicine

Specialty Biomedical Engineering

Date 2017 Jun 10

PMID 28596133

Citations 35

Authors

Daiana D Becker-Santos

Kim M Lonergan

Richard M Gronostajski

Wan L Lam

Affiliations

Soon will be listed here.

Abstract

Emerging evidence indicates that nuclear factor I/B (NFIB), a transcription factor required for proper development and regulation of cellular differentiation in several tissues, also plays critical roles in cancer. Despite being a metastatic driver in small cell lung cancer and melanoma, it has become apparent that NFIB also exhibits tumour suppressive functions in many malignancies. The contradictory contributions of NFIB to both the inhibition and promotion of tumour development and progression, corroborates its diverse and context-dependent roles in many tissues and cell types. Considering the frequent involvement of NFIB in cancer, a better understanding of its multifaceted nature may ultimately benefit the development of novel strategies for the management of a broad spectrum of malignancies. Here we discuss recent findings which bring to light NFIB as a crucial and paradoxical player in cancer.

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References

Mitani Y, Rao P, Futreal P, Roberts D, Stephens P, Zhao Y . Novel chromosomal rearrangements and break points at the t(6;9) in salivary adenoid cystic carcinoma: association with MYB-NFIB chimeric fusion, MYB expression, and clinical outcome. Clin Cancer Res. 2011; 17(22):7003-14. PMC: 3225955. DOI: 10.1158/1078-0432.CCR-11-1870. View

Moon H, Hwang K, Kim J, Kim H, Lee M, Jung E . NFIB is a potential target for estrogen receptor-negative breast cancers. Mol Oncol. 2011; 5(6):538-44. PMC: 5528324. DOI: 10.1016/j.molonc.2011.08.002. View

Dooley A, Winslow M, Chiang D, Banerji S, Stransky N, Dayton T . Nuclear factor I/B is an oncogene in small cell lung cancer. Genes Dev. 2011; 25(14):1470-5. PMC: 3143937. DOI: 10.1101/gad.2046711. View

Engelen E, Akinci U, Bryne J, Hou J, Gontan C, Moen M . Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes. Nat Genet. 2011; 43(6):607-11. DOI: 10.1038/ng.825. View

Grabowska M, Elliott A, DeGraff D, Anderson P, Anumanthan G, Yamashita H . NFI transcription factors interact with FOXA1 to regulate prostate-specific gene expression. Mol Endocrinol. 2014; 28(6):949-64. PMC: 4042066. DOI: 10.1210/me.2013-1213. View

Chaudhry A, Lyons G, Gronostajski R . Expression patterns of the four nuclear factor I genes during mouse embryogenesis indicate a potential role in development. Dev Dyn. 1997; 208(3):313-25. DOI: 10.1002/(SICI)1097-0177(199703)208:3<313::AID-AJA3>3.0.CO;2-L. View

Suzuki H, Aoki K, Chiba K, Sato Y, Shiozawa Y, Shiraishi Y . Mutational landscape and clonal architecture in grade II and III gliomas. Nat Genet. 2015; 47(5):458-68. DOI: 10.1038/ng.3273. View

Chang C, Pasolli H, Giannopoulou E, Guasch G, Gronostajski R, Elemento O . NFIB is a governor of epithelial-melanocyte stem cell behaviour in a shared niche. Nature. 2013; 495(7439):98-102. PMC: 3635831. DOI: 10.1038/nature11847. View

Borromeo M, Savage T, Kollipara R, He M, Augustyn A, Osborne J . ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs. Cell Rep. 2016; 16(5):1259-1272. PMC: 4972690. DOI: 10.1016/j.celrep.2016.06.081. View

10.

Gronostajski R . Roles of the NFI/CTF gene family in transcription and development. Gene. 2000; 249(1-2):31-45. DOI: 10.1016/s0378-1119(00)00140-2. View

11.

Becker-Santos D, Thu K, English J, Pikor L, Martinez V, Zhang M . Developmental transcription factor NFIB is a putative target of oncofetal miRNAs and is associated with tumour aggressiveness in lung adenocarcinoma. J Pathol. 2016; 240(2):161-72. DOI: 10.1002/path.4765. View

12.

Uhlen M, Fagerberg L, Hallstrom B, Lindskog C, Oksvold P, Mardinoglu A . Proteomics. Tissue-based map of the human proteome. Science. 2015; 347(6220):1260419. DOI: 10.1126/science.1260419. View

13.

Xing D, Bakhsh S, Melnyk N, Isacson C, Ho J, Huntsman D . Frequent NFIB-associated Gene Rearrangement in Adenoid Cystic Carcinoma of the Vulva. Int J Gynecol Pathol. 2016; 36(3):289-293. DOI: 10.1097/PGP.0000000000000324. View

14.

Marchio C, Weigelt B, Reis-Filho J . Adenoid cystic carcinomas of the breast and salivary glands (or 'The strange case of Dr Jekyll and Mr Hyde' of exocrine gland carcinomas). J Clin Pathol. 2010; 63(3):220-8. DOI: 10.1136/jcp.2009.073908. View

15.

Rosano L, Spinella F, Bagnato A . Endothelin 1 in cancer: biological implications and therapeutic opportunities. Nat Rev Cancer. 2013; 13(9):637-51. DOI: 10.1038/nrc3546. View

16.

Yates A, Akanni W, Amode M, Barrell D, Billis K, Carvalho-Silva D . Ensembl 2016. Nucleic Acids Res. 2015; 44(D1):D710-6. PMC: 4702834. DOI: 10.1093/nar/gkv1157. View

17.

Persson M, Andren Y, Mark J, Horlings H, Persson F, Stenman G . Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck. Proc Natl Acad Sci U S A. 2009; 106(44):18740-4. PMC: 2773970. DOI: 10.1073/pnas.0909114106. View

18.

Yang Z, Imoto I, Pimkhaokham A, Shimada Y, Sasaki K, Oka M . A novel amplicon at 9p23 - 24 in squamous cell carcinoma of the esophagus that lies proximal to GASC1 and harbors NFIB. Jpn J Cancer Res. 2001; 92(4):423-8. PMC: 5926726. DOI: 10.1111/j.1349-7006.2001.tb01112.x. View

19.

Fujita S, Ito T, Mizutani T, Minoguchi S, Yamamichi N, Sakurai K . miR-21 Gene expression triggered by AP-1 is sustained through a double-negative feedback mechanism. J Mol Biol. 2008; 378(3):492-504. DOI: 10.1016/j.jmb.2008.03.015. View

20.

Mitani Y, Li J, Rao P, Zhao Y, Bell D, Lippman S . Comprehensive analysis of the MYB-NFIB gene fusion in salivary adenoid cystic carcinoma: Incidence, variability, and clinicopathologic significance. Clin Cancer Res. 2010; 16(19):4722-31. PMC: 5862426. DOI: 10.1158/1078-0432.CCR-10-0463. View