Protective Effects of Gingerol on Streptozotocin-induced Sporadic Alzheimer's Disease: Emphasis on Inhibition of β-amyloid, COX-2, Alpha-, Beta - Secretases and APH1a

Overview

Journal Sci Rep

Specialty Science

Date 2017 Jun 8

PMID 28588301

Citations 28

Authors

Ali M El Halawany

Nesrine S El Sayed

Hossam M Abdallah

Riham Salah El Dine

Affiliations

Soon will be listed here.

Abstract

Gingerol is a major dietary compound that occurs in several plants belonging to the Zingiberaceae family. In the current study, the protective effect of gingerol on STZ-induced sporadic Alzheimer's disease (SAD) was determined. Gingerol was isolated from the seeds of Aframomum melegueta K. Schum and tested at doses of 10 and 20 mg/kgbwt for its possible effect on the SAD model in mice, using celecoxib (30 mg/kg bwt) as a reference standard. The curative effects of gingerol were assessed through measurement of β-amyloid (Aβ-42), α-, β- secretases, APH1a and COX-2 levels. In addition, improvement in the cognitive deficit in mice after treatment was confirmed using the water maze and Y-maze with intra-maze cues. Gingerol improved the cognitive and behavioral impairment and AD-like pathology in streptozotocin model mice. These beneficial effects occurred with an increase in α-secretase activity and a decrease in cerebral Aβ-42, β- secretase, APH1a activity and COX-2-linked neuro-inflammation.

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