Inflammation and Alzheimer's Disease: Mechanisms and Therapeutic Implications by Natural Products

Overview

Journal Mediators Inflamm

Publisher Wiley

Specialties Biochemistry
Pathology

Date 2021 Aug 12

PMID 34381308

Citations 23

Authors

Mashoque Ahmad Rather

Andleeb Khan

Saeed Alshahrani

Hina Rashid

Marwa Qadri

Summya Rashid

Rana M Alsaffar

Mohammad Amjad Kamal

Muneeb U Rehman

Affiliations

Soon will be listed here.

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder with no clear causative event making the disease difficult to diagnose and treat. The pathological hallmarks of AD include amyloid plaques, neurofibrillary tangles, and widespread neuronal loss. Amyloid-beta has been extensively studied and targeted to develop an effective disease-modifying therapy, but the success rate in clinical practice is minimal. Recently, neuroinflammation has been focused on as the event in AD progression to be targeted for therapies. Various mechanistic pathways including cytokines and chemokines, complement system, oxidative stress, and cyclooxygenase pathways are linked to neuroinflammation in the AD brain. Many cells including microglia, astrocytes, and oligodendrocytes work together to protect the brain from injury. This review is focused to better understand the AD inflammatory and immunoregulatory processes to develop novel anti-inflammatory drugs to slow down the progression of AD.

Citing Articles

Mechanisms and Emerging Regulators of Neuroinflammation: Exploring New Therapeutic Strategies for Neurological Disorders.

Kim M, Lee J Curr Issues Mol Biol. 2025; 47(1).

PMID: 39852123 PMC: 11763386. DOI: 10.3390/cimb47010008.

Unveiling the multifaceted pathogenesis and therapeutic drugs of Alzheimer's disease: A comprehensive review.

Peng L, Zhang Z, Li Q, Song Z, Yan C, Ling H Heliyon. 2024; 10(20):e39217.

PMID: 39629139 PMC: 11612466. DOI: 10.1016/j.heliyon.2024.e39217.

Navigating Alzheimer's Disease Mouse Models: Age-Related Pathology and Cognitive Deficits.

De Plano L, Saitta A, Oddo S, Caccamo A Biomolecules. 2024; 14(11).

PMID: 39595581 PMC: 11592094. DOI: 10.3390/biom14111405.

Lactocaseibacillus-deglycosylated isoflavones prevent Aβ 40-induced Alzheimer's disease in a rat model.

Liu C, Young Z, Shih T, Pan T, Lee C AMB Express. 2024; 14(1):90.

PMID: 39105988 PMC: 11303605. DOI: 10.1186/s13568-024-01735-y.

Genus : Exploring Its Potential as a Functional Food Ingredient with Neuroprotective Properties Mediated by Antioxidant and Anti-Inflammatory Mechanisms.

Merecz-Sadowska A, Sitarek P, Zajdel K, Sztandera W, Zajdel R Int J Mol Sci. 2024; 25(14).

PMID: 39063085 PMC: 11277136. DOI: 10.3390/ijms25147843.

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