Injectable Hydrogels for Cartilage and Bone Tissue Engineering

Overview

Journal Bone Res

Specialties Endocrinology
Orthopedics

Date 2017 Jun 7

PMID 28584674

Citations 300

Authors

Mei Liu

Xin Zeng

Chao Ma

Huan Yi

Zeeshan Ali

Xianbo Mou

Song Li

Yan Deng

Nongyue He

Affiliations

Soon will be listed here.

Abstract

Tissue engineering has become a promising strategy for repairing damaged cartilage and bone tissue. Among the scaffolds for tissue-engineering applications, injectable hydrogels have demonstrated great potential for use as three-dimensional cell culture scaffolds in cartilage and bone tissue engineering, owing to their high water content, similarity to the natural extracellular matrix (ECM), porous framework for cell transplantation and proliferation, minimal invasive properties, and ability to match irregular defects. In this review, we describe the selection of appropriate biomaterials and fabrication methods to prepare novel injectable hydrogels for cartilage and bone tissue engineering. In addition, the biology of cartilage and the bony ECM is also summarized. Finally, future perspectives for injectable hydrogels in cartilage and bone tissue engineering are discussed.

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