Role of the MicroRNA-29 Family in Fibrotic Skin Diseases

Overview

Journal Biomed Rep

Specialty Biochemistry

Date 2017 Jun 7

PMID 28584629

Citations 21

Authors

Duygu Harmanci

Erdogan Pekcan Erkan

Ayse Kocak

Gul Guner Akdogan

Affiliations

Soon will be listed here.

Abstract

Fibrotic skin diseases are characterized by the accumulation of collagen. The hallmarks of fibrotic skin diseases are unbalanced fibroblast proliferation and differentiation, extracellular matrix production and transforming growth factor-β signalling. Numerous studies have investigated the possibility that microRNAs (miRNAs or miRs) are involved in the pathogenesis of certain fibrotic diseases, including skin, heart, lung and liver diseases. miRNAs are a class of small non-coding RNAs, which modify gene expression by binding to target messenger RNA (mRNA) and blocking the translation or inducing the degradation of target mRNA. The biological relevance of miRNAs has been investigated in physiological and pathological conditions, and there is increasing evidence that the miR-29 family is associated with fibrotic diseases. The aim of the present review is to provide an up-to-date summary of current knowledge on the latest developments associated with the miR-29 family and fibrotic skin diseases.

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