A Brief Review: Adipose-derived Stem Cells and Their Therapeutic Potential in Cardiovascular Diseases

Overview

Journal Stem Cell Res Ther

Publisher Biomed Central

Date 2017 Jun 7

PMID 28583198

Citations 66

Authors

Teng Ma

Jiacheng Sun

Zhenao Zhao

Wei Lei

Yueqiu Chen

Xu Wang

Junjie Yang

Zhenya Shen

Affiliations

Soon will be listed here.

Abstract

Adipose-derived stem cells (ADSCs) are easily obtained and expanded, and have emerged as a novel source of adult stem cells for the treatment of cardiovascular diseases. These cells have been shown to have the capability of differentiating into cardiomyocytes, vascular smooth muscle cells, and endothelial cells. Furthermore, ADSCs secrete a series of paracrine factors to promote neovascularization, reduce apoptosis, and inhibit fibrosis, which contributes to cardiac regeneration. As a novel therapy in the regenerative field, ADSCs still face various limitations, such as low survival and engraftment. Thus, engineering and pharmacological studies have been conducted to solve these problems. Investigations have moved into phase I and II clinical trials examining the safety and efficacy of ADSCs in the setting of myocardial infarction. In this review, we discuss the differentiation and paracrine functions of ADSCs, the strategies promoting their therapeutic efficacy, and their clinical usage.

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References

Slevin M, Kumar P, Gaffney J, Kumar S, Krupinski J . Can angiogenesis be exploited to improve stroke outcome? Mechanisms and therapeutic potential. Clin Sci (Lond). 2006; 111(3):171-83. DOI: 10.1042/CS20060049. View

Yang M, Zhang G, Wang T, Wang X, Tang Y, Huang H . TBX18 gene induces adipose-derived stem cells to differentiate into pacemaker-like cells in the myocardial microenvironment. Int J Mol Med. 2016; 38(5):1403-1410. PMC: 5065308. DOI: 10.3892/ijmm.2016.2736. View

Follin B, Juhl M, Cohen S, Pedersen A, Gad M, Kastrup J . Human adipose-derived stromal cells in a clinically applicable injectable alginate hydrogel: Phenotypic and immunomodulatory evaluation. Cytotherapy. 2015; 17(8):1104-18. DOI: 10.1016/j.jcyt.2015.04.008. View

Song K, Wang Z, Li W, Zhang C, Lim M, Liu T . In vitro culture, determination, and directed differentiation of adult adipose-derived stem cells towards cardiomyocyte-like cells induced by angiotensin II. Appl Biochem Biotechnol. 2013; 170(2):459-70. DOI: 10.1007/s12010-013-0210-6. View

Jeon E, Moon H, Lee M, Song H, Kim Y, Bae Y . Sphingosylphosphorylcholine induces differentiation of human mesenchymal stem cells into smooth-muscle-like cells through a TGF-beta-dependent mechanism. J Cell Sci. 2006; 119(Pt 23):4994-5005. DOI: 10.1242/jcs.03281. View

Miranville A, Heeschen C, Sengenes C, Curat C, Busse R, Bouloumie A . Improvement of postnatal neovascularization by human adipose tissue-derived stem cells. Circulation. 2004; 110(3):349-55. DOI: 10.1161/01.CIR.0000135466.16823.D0. View

Hamdi H, Planat-Benard V, Bel A, Neamatalla H, Saccenti L, Calderon D . Long-term functional benefits of epicardial patches as cell carriers. Cell Transplant. 2012; 23(1):87-96. DOI: 10.3727/096368912X658836. View

Cao Y, Sun Z, Liao L, Meng Y, Han Q, Zhao R . Human adipose tissue-derived stem cells differentiate into endothelial cells in vitro and improve postnatal neovascularization in vivo. Biochem Biophys Res Commun. 2005; 332(2):370-9. DOI: 10.1016/j.bbrc.2005.04.135. View

Uysal C, Tobita M, Hyakusoku H, Mizuno H . The Effect of Bone-Marrow-Derived Stem Cells and Adipose-Derived Stem Cells on Wound Contraction and Epithelization. Adv Wound Care (New Rochelle). 2014; 3(6):405-413. PMC: 4048969. DOI: 10.1089/wound.2014.0539. View

10.

Berardi G, Rebelatto C, Tavares H, Ingberman M, Shigunov P, Barchiki F . Transplantation of SNAP-treated adipose tissue-derived stem cells improves cardiac function and induces neovascularization after myocardium infarct in rats. Exp Mol Pathol. 2010; 90(2):149-56. DOI: 10.1016/j.yexmp.2010.11.005. View

11.

Finegold J, Asaria P, Francis D . Mortality from ischaemic heart disease by country, region, and age: statistics from World Health Organisation and United Nations. Int J Cardiol. 2012; 168(2):934-45. PMC: 3819990. DOI: 10.1016/j.ijcard.2012.10.046. View

12.

Wang J, Xiang B, Deng J, Lin H, Zheng D, Freed D . Externally Applied Static Magnetic Field Enhances Cardiac Retention and Functional Benefit of Magnetically Iron-Labeled Adipose-Derived Stem Cells in Infarcted Hearts. Stem Cells Transl Med. 2016; 5(10):1380-1393. PMC: 5031175. DOI: 10.5966/sctm.2015-0220. View

13.

Lee C, Shin S, Lee J, Seo H, Lim K, Kim H . MicroRNA-Mediated Down-Regulation of Apoptosis Signal-Regulating Kinase 1 (ASK1) Attenuates the Apoptosis of Human Mesenchymal Stem Cells (MSCs) Transplanted into Infarcted Heart. Int J Mol Sci. 2016; 17(10). PMC: 5085777. DOI: 10.3390/ijms17101752. View

14.

Kang T, Jones T, Naddell C, Bacanamwo M, Calvert J, Thompson W . Adipose-Derived Stem Cells Induce Angiogenesis via Microvesicle Transport of miRNA-31. Stem Cells Transl Med. 2016; 5(4):440-50. PMC: 4798737. DOI: 10.5966/sctm.2015-0177. View

15.

Rangappa S, Fen C, Lee E, Bongso A, Sim E, Wei E . Transformation of adult mesenchymal stem cells isolated from the fatty tissue into cardiomyocytes. Ann Thorac Surg. 2003; 75(3):775-9. DOI: 10.1016/s0003-4975(02)04568-x. View

16.

Houtgraaf J, den Dekker W, van Dalen B, Springeling T, De Jong R, van Geuns R . First experience in humans using adipose tissue-derived regenerative cells in the treatment of patients with ST-segment elevation myocardial infarction. J Am Coll Cardiol. 2012; 59(5):539-40. DOI: 10.1016/j.jacc.2011.09.065. View

17.

Pendleton C, Li Q, Chesler D, Yuan K, Guerrero-Cazares H, Quinones-Hinojosa A . Mesenchymal stem cells derived from adipose tissue vs bone marrow: in vitro comparison of their tropism towards gliomas. PLoS One. 2013; 8(3):e58198. PMC: 3595264. DOI: 10.1371/journal.pone.0058198. View

18.

Togliatto G, Dentelli P, Gili M, Gallo S, Deregibus C, Biglieri E . Obesity reduces the pro-angiogenic potential of adipose tissue stem cell-derived extracellular vesicles (EVs) by impairing miR-126 content: impact on clinical applications. Int J Obes (Lond). 2015; 40(1):102-11. PMC: 4722244. DOI: 10.1038/ijo.2015.123. View

19.

Wang K, Jiang Z, Webster K, Chen J, Hu H, Zhou Y . Enhanced Cardioprotection by Human Endometrium Mesenchymal Stem Cells Driven by Exosomal MicroRNA-21. Stem Cells Transl Med. 2017; 6(1):209-222. PMC: 5442741. DOI: 10.5966/sctm.2015-0386. View

20.

Han D, Huang W, Ma S, Chen J, Gao L, Liu T . Ghrelin improves functional survival of engrafted adipose-derived mesenchymal stem cells in ischemic heart through PI3K/Akt signaling pathway. Biomed Res Int. 2015; 2015:858349. PMC: 4387976. DOI: 10.1155/2015/858349. View