A Potential Role of Esophageal Cancer Related Gene-4 for Atrial Fibrillation

Overview

Journal Sci Rep

Specialty Science

Date 2017 Jun 5

PMID 28578429

Citations 6

Authors

Li Huang

Hua Yu

Xinrong Fan

Xue Li

Liang Mao

Jun Cheng

Xiaorong Zeng

Xitong Dang

Affiliations

Soon will be listed here.

Abstract

Epidemiological studies have shown a strong correlation between tumor and AF. However, the molecular link between tumor and AF remains unknown. ECRG4, a tumor suppressor gene that is expressed in the A-V node and in sporadic ventricular myocytes, inhibits tumorigenesis and monitors tissue homeostasis by functioning as a 'sentinel' molecule gauging inflammatory and cell proliferative responses. To explore the potential physiological function of Ecrg4 in heart, we evaluated its distribution in heart, analyzed its expression in patients with persistent AF and in a canine AF model, and dissected the molecular events downstream of Ecrg4. The results showed that the level of Ecrg4 expression is homogenously high in atria and the conduction systems and in sporadic ventricular myocytes. Importantly, the expression of Ecrg4 was significantly decreased in atrial appendages of AF patients than patients with SR. Moreover, in rapid pacing canine AF models, the expression of ECRG4 in atria was significantly decreased compared to that of the controls. Mechanistically, knockdown ECRG4 in atrial myocytes significantly shortened the APDs, inhibited the expression of Gja1, and activated pro-inflammatory cascades and genes involved in cardiac remodeling. These results suggest that Ecrg4 may play a critical role in the pathogenesis of AF.

Citing Articles

Esophageal Cancer-Related Gene-4 Contributes to Lipopolysaccharide-Induced Ion Channel Dysfunction in hiPSC-Derived Cardiomyocytes.

Xu Q, Zhang X, Hao M, Dang X, Xu Q, Cyganek L J Inflamm Res. 2024; 17:10183-10197.

PMID: 39649417 PMC: 11624686. DOI: 10.2147/JIR.S470828.

A potential link between aberrant expression of ECRG4 and atrial fibrillation.

Zhang Z, Wang W, Zhang Y, You X, Wu J Front Oncol. 2023; 13:1031128.

PMID: 36910669 PMC: 9992723. DOI: 10.3389/fonc.2023.1031128.

Cardiac Expression of Esophageal Cancer-Related Gene-4 is Regulated by Sp1 and is a Potential Early Target of Doxorubicin-Induced Cardiotoxicity.

Long D, Chen C, Li W, Peng W, Li D, Zhou R Cardiovasc Toxicol. 2022; 22(5):404-418.

PMID: 35129819 DOI: 10.1007/s12012-022-09722-0.

Potential Target Genes in the Development of Atrial Fibrillation: A Comprehensive Bioinformatics Analysis.

Liu L, Yu Y, Hu L, Dong Q, Hu F, Zhu L Med Sci Monit. 2021; 27:e928366.

PMID: 33741890 PMC: 7989062. DOI: 10.12659/MSM.928366.

Potential functions of esophageal cancer-related gene-4 in the cardiovascular system.

Zhou R, Liu Y, Huang W, Dang X Front Med. 2019; 13(6):639-645.

PMID: 31468282 DOI: 10.1007/s11684-019-0701-0.

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