Transcription Factor Patterns Cells in the Mouse Kidney Collecting Ducts

Overview

Journal Elife

Specialty Biology

Date 2017 Jun 4

PMID 28577314

Citations 42

Authors

Max Werth

Kai M Schmidt-Ott

Thomas Leete

Andong Qiu

Christian Hinze

Melanie Viltard

Neal Paragas

Carrie J Shawber

Wenqiang Yu

Peter Lee

Xia Chen

Abby Sarkar

Weiyi Mu

Alexander Rittenberg

Chyuan-Sheng Lin

Jan Kitajewski

Qais Al-Awqati

Jonathan Barasch

Affiliations

Soon will be listed here.

Abstract

Although most nephron segments contain one type of epithelial cell, the collecting ducts consists of at least two: intercalated (IC) and principal (PC) cells, which regulate acid-base and salt-water homeostasis, respectively. In adult kidneys, these cells are organized in rosettes suggesting functional interactions. Genetic studies in mouse revealed that transcription factor coordinates IC and PC development. induces the expression of IC specific genes, including specific H-ATPase subunits and in turn, initiates Notch signaling in PCs but inhibits Notch signaling in ICs. inactivation deletes ICs, whereas inactivation results in the forfeiture of discrete IC and PC identities. Thus, is a critical regulator of IC-PC patterning, acting cell-autonomously in ICs, and non-cell-autonomously in PCs. As a result, regulates the diversification of cell types which is the central characteristic of 'salt and pepper' epithelia and distinguishes the collecting duct from all other nephron segments.

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