Impaired Autophagy and Defective T Cell Homeostasis in Mice with T Cell-Specific Deletion of Receptor for Activated C Kinase 1

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2017 Jun 3

PMID 28572806

Citations 9

Authors

Guihua Qiu

Jian Liu

Qianqian Cheng

Qingyang Wang

Zhaofei Jing

Yujun Pei

Min Zhao

Jing Wang

Jessie Yanxiang Guo

Jiyan Zhang

Affiliations

Soon will be listed here.

Abstract

Autophagy plays a central role in maintaining T cell homeostasis. Our previous study has shown that hepatocyte-specific deficiency of receptor for activated C kinase 1 (RACK1) leads to lipid accumulation in the liver, accompanied by impaired autophagy, but its role in T cells remains unclear. Here, we report that mice with T cell-specific deletion of RACK1 exhibit normal intrathymic development of conventional T cells and regulatory T (Treg) cells but reduced numbers of peripheral CD4 and CD8 T cells. Such defects are cell intrinsic with impaired mitochondrial clearance, increased sensitivity to cell death, and decreased proliferation that could be explained by impaired autophagy. Furthermore, RACK1 is essential for invariant natural T cell development. , T cell-specific loss of RACK1 dampens concanavalin A-induced acute liver injury. Our data suggest that RACK1 is a key regulator of T cell homeostasis.

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