Dietary Nitrate Does Not Modify Blood Pressure and Cardiac Output at Rest and During Exercise in Older Adults: a Randomised Cross-over Study

Overview

Journal Int J Food Sci Nutr

Publisher Informa Healthcare

Specialty Nutritional Sciences

Date 2017 Jun 1

PMID 28562133

Citations 13

Authors

C Oggioni

D G Jakovljevic

M Klonizakis

A W Ashor

A Ruddock

M Ranchordas

E Williams

M Siervo

Affiliations

Soon will be listed here.

Abstract

Dietary nitrate (NO) supplementation has been associated with improved vascular and metabolic health. We conducted a double-blind, cross-over, placebo-controlled RCT to investigate the effects of 7-d consumption of beetroot juice compared with placebo on (1) blood pressure (BP) measured in resting conditions and during exercise, (2) cardiac and peripheral vascular function and (3) biomarkers of inflammation, oxidative stress and endothelial integrity. Twenty non-smoking healthy participants aged 60-75 years and BMI 20.0-29.9 kg/m were recruited. Measurement was conducted before and after each 7-d intervention period. Consumption of NO had no effect on resting systolic and diastolic BP. NO consumption did not improve indexes of central and peripheral cardiac function responses during cardiopulmonary exercise testing. Dietary NO supplementation did not modify biomarkers of inflammation, oxidative stress and endothelial integrity. This study does not support the short-term benefits of dietary NO supplementation on physiological and biochemical markers of vascular health in older healthy adults.

Citing Articles

Beetroot juice supplementation and exercise performance: is there more to the story than just nitrate?.

Zoughaib W, Fry M, Singhal A, Coggan A Front Nutr. 2024; 11:1347242.

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Acute beetroot juice consumption does not alter cerebral autoregulation or cardiovagal baroreflex sensitivity during lower-body negative pressure in healthy adults.

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