The Significant Effects of Puberty on the Genetic Diathesis of Binge Eating in Girls

Overview

Journal Int J Eat Disord

Publisher Wiley

Specialty Social Sciences

Date 2017 Jun 1

PMID 28560852

Citations 22

Authors

Kelly L Klump

Kristen M Culbert

Shannon OConnor

Natasha Fowler

S Alexandra Burt

Affiliations

Soon will be listed here.

Abstract

Objective: Recent data show significant phenotypic and genetic associations between ovarian hormones and binge eating in adulthood. Theories of hormonal risk focus on puberty and the possibility that hormone activation induces changes in genetic effects that then lead to differential risk for binge eating in postpuberty and adulthood. Although this theory is difficult to test in humans, an indirect test is to examine whether genetic influences on binge eating increase during the pubertal period in girls. Prior work has shown pubertal increases in genetic influences on overall disordered eating symptoms, but no study to date has examined binge eating. The present study was the first to examine these increases for binge eating.

Methods: Participants included 1,568 female twins (aged 8-25 years) from the Michigan State University Twin Registry. Binge eating and pubertal development were assessed with self-report questionnaires.

Results: Twin moderation models showed significant linear increases in genetic effects from prepuberty (5%) to postpuberty (42%), even after controlling for the effects of age and body mass index.

Discussion: Results provide critical support for increased genetic influences on binge eating during puberty. Additional studies are needed to identify hormonal mechanisms and fully test contemporary models of ovarian hormone risk.

Citing Articles

Association of body mass index with progression from binge-eating behavior into binge-eating disorder among adolescents in the United States: A prospective analysis of pooled data.

Al-Shoaibi A, Lavender J, Kim S, Shao I, Ganson K, Testa A Appetite. 2024; 200:107419.

PMID: 38759754 PMC: 11610364. DOI: 10.1016/j.appet.2024.107419.

Distinct Topological Properties of the Reward Anticipation Network in Preadolescent Children With Binge Eating Disorder Symptoms.

Martin E, Cao M, Schulz K, Hildebrandt T, Sysko R, Berner L J Am Acad Child Adolesc Psychiatry. 2024; 63(11):1158-1168.

PMID: 38461893 PMC: 11380707. DOI: 10.1016/j.jaac.2024.02.015.

Differential genetic associations between dimensions of eating disorders and alcohol involvement in late adolescent twins.

Qi B, Thornton L, Breiner C, Kuja-Halkola R, Baker J, Lichtenstein P Alcohol Clin Exp Res (Hoboken). 2023; 47(9):1677-1689.

PMID: 38051153 PMC: 10699207. DOI: 10.1111/acer.15150.

Estrogen moderation of genetic influences on eating disorder symptoms during gonadarche in girls: Specific effects on binge eating.

Rolan E, Mikhail M, Culbert K, Burt S, Klump K Psychoneuroendocrinology. 2023; 158:106384.

PMID: 37708824 PMC: 10880121. DOI: 10.1016/j.psyneuen.2023.106384.

The organizational role of ovarian hormones during puberty on risk for binge-like eating in rats.

Hildebrandt B, Lee J, Culbert K, Sisk C, Johnson A, Klump K Physiol Behav. 2023; 265:114177.

PMID: 36967031 PMC: 10121844. DOI: 10.1016/j.physbeh.2023.114177.

References

Peeters H, van Gestel S, Vlietinck R, Derom C, DEROM R . Validation of a telephone zygosity questionnaire in twins of known zygosity. Behav Genet. 1998; 28(3):159-63. DOI: 10.1023/a:1021416112215. View

Luo X, Donnellan M, Burt S, Klump K . The dimensional nature of eating pathology: Evidence from a direct comparison of categorical, dimensional, and hybrid models. J Abnorm Psychol. 2016; 125(5):715-26. PMC: 5050027. DOI: 10.1037/abn0000174. View

Klump K, Culbert K, Slane J, Burt S, Sisk C, Nigg J . The effects of puberty on genetic risk for disordered eating: evidence for a sex difference. Psychol Med. 2011; 42(3):627-37. PMC: 3697115. DOI: 10.1017/S0033291711001541. View

Bulik C, Sullivan P, Kendler K . Heritability of binge-eating and broadly defined bulimia nervosa. Biol Psychiatry. 1998; 44(12):1210-8. DOI: 10.1016/s0006-3223(98)00280-7. View

Petersen A, Crockett L, Richards M, Boxer A . A self-report measure of pubertal status: Reliability, validity, and initial norms. J Youth Adolesc. 2013; 17(2):117-33. DOI: 10.1007/BF01537962. View

Klump K, Burt S, McGue M, Iacono W . Changes in genetic and environmental influences on disordered eating across adolescence: a longitudinal twin study. Arch Gen Psychiatry. 2007; 64(12):1409-15. DOI: 10.1001/archpsyc.64.12.1409. View

Purcell S . Variance components models for gene-environment interaction in twin analysis. Twin Res. 2003; 5(6):554-71. DOI: 10.1375/136905202762342026. View

Berg K, Peterson C, Frazier P, Crow S . Convergence of scores on the interview and questionnaire versions of the Eating Disorder Examination: a meta-analytic review. Psychol Assess. 2011; 23(3):714-24. PMC: 3437603. DOI: 10.1037/a0023246. View

Klump K, Racine S, Hildebrandt B, Burt S, Neale M, Sisk C . Ovarian Hormone Influences on Dysregulated Eating: A Comparison of Associations in Women with versus without Binge Episodes. Clin Psychol Sci. 2014; 2(4):545-559. PMC: 4203460. DOI: 10.1177/2167702614521794. View

10.

Klump K, Holly A, Iacono W, McGue M, Willson L . Physical similarity and twin resemblance for eating attitudes and behaviors: a test of the equal environments assumption. Behav Genet. 2000; 30(1):51-8. DOI: 10.1023/a:1002038610763. View

11.

Klump K, Keel P, Sisk C, Burt S . Preliminary evidence that estradiol moderates genetic influences on disordered eating attitudes and behaviors during puberty. Psychol Med. 2010; 40(10):1745-53. PMC: 2928391. DOI: 10.1017/S0033291709992236. View

12.

Culbert K, Burt S, Sisk C, Nigg J, Klump K . The effects of circulating testosterone and pubertal maturation on risk for disordered eating symptoms in adolescent males. Psychol Med. 2014; 44(11):2271-86. PMC: 4324383. DOI: 10.1017/S0033291713003073. View

13.

Klump K, Perkins P, Burt S, McGue M, Iacono W . Puberty moderates genetic influences on disordered eating. Psychol Med. 2007; 37(5):627-34. DOI: 10.1017/S0033291707000189. View

14.

Klump K, Burt S . The Michigan State University Twin Registry (MSUTR): genetic, environmental and neurobiological influences on behavior across development. Twin Res Hum Genet. 2007; 9(6):971-7. DOI: 10.1375/183242706779462868. View

15.

Klump K, Keel P, Racine S, Burt S, Burt A, Neale M . The interactive effects of estrogen and progesterone on changes in emotional eating across the menstrual cycle. J Abnorm Psychol. 2012; 122(1):131-7. PMC: 3570621. DOI: 10.1037/a0029524. View

16.

Klump K, Culbert K, Sisk C . Sex Differences in Binge Eating: Gonadal Hormone Effects Across Development. Annu Rev Clin Psychol. 2017; 13:183-207. DOI: 10.1146/annurev-clinpsy-032816-045309. View

17.

OConnor S, Burt S, VanHuysse J, Klump K . What drives the association between weight-conscious peer groups and disordered eating? Disentangling genetic and environmental selection from pure socialization effects. J Abnorm Psychol. 2016; 125(3):356-68. PMC: 4824549. DOI: 10.1037/abn0000132. View

18.

von Ranson K, Klump K, Iacono W, McGue M . The Minnesota Eating Behavior Survey: a brief measure of disordered eating attitudes and behaviors. Eat Behav. 2005; 6(4):373-92. DOI: 10.1016/j.eatbeh.2004.12.002. View

19.

Klump K, Burt S, Spanos A, McGue M, Iacono W, Wade T . Age differences in genetic and environmental influences on weight and shape concerns. Int J Eat Disord. 2009; 43(8):679-88. PMC: 2891330. DOI: 10.1002/eat.20772. View

20.

Reichborn-Kjennerud T, Bulik C, Kendler K, Roysamb E, Maes H, Tambs K . Gender differences in binge-eating: a population-based twin study. Acta Psychiatr Scand. 2003; 108(3):196-202. DOI: 10.1034/j.1600-0447.2003.00106.x. View