Ovarian Hormone Influences on Dysregulated Eating: A Comparison of Associations in Women with Versus Without Binge Episodes

Overview

Journal Clin Psychol Sci

Publisher Sage Publications

Specialty Psychiatry

Date 2014 Oct 25

PMID 25343062

Citations 49

Authors

Kelly L Klump

Sarah E Racine

Britny Hildebrandt

S Alexandra Burt

Michael Neale

Cheryl L Sisk

Steven Boker

Pamela K Keel

Affiliations

Soon will be listed here.

Abstract

Changes in ovarian hormones predict changes in emotional eating across the menstrual cycle. However, prior studies have not examined whether the nature of associations varies across dysregulated eating severity. The current study determined whether the strength and/or nature of hormone/dysregulated eating associations differ based on the presence of clinically diagnosed binge episodes (BEs). Participants included 28 women with BEs and 417 women without BEs who provided salivary hormone samples, ratings of emotional eating, and BE frequency for 45 days. Results revealed stronger associations between dysregulated eating and ovarian hormones in women with BEs as compared to women without BEs. The nature of associations also differed, as progesterone moderated the effects of lower estradiol levels on dysregulated eating in women with BEs only. Although hormone/dysregulated eating associations are present across the spectrum of pathology, the nature of associations may vary in ways that have implications for etiological models and treatment.

Citing Articles

Sex-specific associations between body composition and depression among U.S. adults: a cross-sectional study.

Li Y, Li J, Sun T, He Z, Liu C, Li Z Lipids Health Dis. 2025; 24(1):15.

PMID: 39827131 PMC: 11742532. DOI: 10.1186/s12944-025-02437-5.

GLP-1 and Its Analogs: Does Sex Matter?.

Borchers S, Skibicka K Endocrinology. 2024; 166(2).

PMID: 39715341 PMC: 11733500. DOI: 10.1210/endocr/bqae165.

Daily estradiol and progesterone levels moderate genetic and environmental influences on emotional eating across 45 consecutive days in female twins.

Klump K, Mikhail M, Anaya C, Keel P, Culbert K, Sisk C Psychol Med. 2024; :1-9.

PMID: 39628454 PMC: 11650152. DOI: 10.1017/S0033291724002770.

Ovarian hormones and eating disorders.

Young J Front Psychol. 2024; 15:1467795.

PMID: 39315050 PMC: 11416966. DOI: 10.3389/fpsyg.2024.1467795.

Ovarian Hormones and Binge Eating in Adulthood: Summary of Findings and Implications for Individual Differences in Risk in Women.

Klump K, Culbert K, Johnson A, Sisk C Curr Dir Psychol Sci. 2024; 32(6):471-478.

PMID: 38313831 PMC: 10836831. DOI: 10.1177/09637214231192835.

References

Bulik C, Sullivan P, Kendler K . Heritability of binge-eating and broadly defined bulimia nervosa. Biol Psychiatry. 1998; 44(12):1210-8. DOI: 10.1016/s0006-3223(98)00280-7. View

Gray J, Wade G . Food intake, body weight, and adiposity in female rats: actions and interactions of progestins and antiestrogens. Am J Physiol. 1981; 240(5):E474-81. DOI: 10.1152/ajpendo.1981.240.5.E474. View

Lester N, Keel P, Lipson S . Symptom fluctuation in bulimia nervosa: relation to menstrual-cycle phase and cortisol levels. Psychol Med. 2003; 33(1):51-60. DOI: 10.1017/s0033291702006815. View

Price W, Torem M, DiMarzio L . Premenstrual exacerbation of bulimia. Psychosomatics. 1987; 28(7):378-9. DOI: 10.1016/s0033-3182(87)72511-0. View

Ostlund H, Keller E, Hurd Y . Estrogen receptor gene expression in relation to neuropsychiatric disorders. Ann N Y Acad Sci. 2004; 1007:54-63. DOI: 10.1196/annals.1286.006. View

Klump K, Suisman J, Culbert K, Kashy D, Sisk C . Binge eating proneness emerges during puberty in female rats: a longitudinal study. J Abnorm Psychol. 2011; 120(4):948-55. PMC: 3697134. DOI: 10.1037/a0023600. View

Boggiano M, Artiga A, Pritchett C, Chandler-Laney P, Smith M, Eldridge A . High intake of palatable food predicts binge-eating independent of susceptibility to obesity: an animal model of lean vs obese binge-eating and obesity with and without binge-eating. Int J Obes (Lond). 2007; 31(9):1357-67. DOI: 10.1038/sj.ijo.0803614. View

Dawson J, Richter A . Probing three-way interactions in moderated multiple regression: development and application of a slope difference test. J Appl Psychol. 2006; 91(4):917-26. DOI: 10.1037/0021-9010.91.4.917. View

Sinclair E, Culbert K, Gradl D, Richardson K, Klump K, Sisk C . Differential mesocorticolimbic responses to palatable food in binge eating prone and binge eating resistant female rats. Physiol Behav. 2015; 152(Pt A):249-56. PMC: 5645798. DOI: 10.1016/j.physbeh.2015.10.012. View

10.

van Strien T . Ice-cream consumption, tendency toward overeating, and personality. Int J Eat Disord. 2000; 28(4):460-4. DOI: 10.1002/1098-108x(200012)28:4<460::aid-eat16>3.0.co;2-a. View

11.

Fairburn C, Beglin S . Assessment of eating disorders: interview or self-report questionnaire?. Int J Eat Disord. 1994; 16(4):363-70. View

12.

Racine S, Burt S, Iacono W, McGue M, Klump K . Dietary restraint moderates genetic risk for binge eating. J Abnorm Psychol. 2010; 120(1):119-28. PMC: 3057961. DOI: 10.1037/a0020895. View

13.

Edler C, Lipson S, Keel P . Ovarian hormones and binge eating in bulimia nervosa. Psychol Med. 2006; 37(1):131-41. DOI: 10.1017/S0033291706008956. View

14.

Varma M, Chai J, Meguid M, Laviano A, Gleason J, Yang Z . Effect of estradiol and progesterone on daily rhythm in food intake and feeding patterns in Fischer rats. Physiol Behav. 2000; 68(1-2):99-107. DOI: 10.1016/s0031-9384(99)00152-3. View

15.

Keel P, Mitchell J, Miller K, Davis T, Crow S . Long-term outcome of bulimia nervosa. Arch Gen Psychiatry. 1999; 56(1):63-9. DOI: 10.1001/archpsyc.56.1.63. View

16.

Klump K . Puberty as a critical risk period for eating disorders: a review of human and animal studies. Horm Behav. 2013; 64(2):399-410. PMC: 3761220. DOI: 10.1016/j.yhbeh.2013.02.019. View

17.

Insel T, Cuthbert B, Garvey M, Heinssen R, Pine D, Quinn K . Research domain criteria (RDoC): toward a new classification framework for research on mental disorders. Am J Psychiatry. 2010; 167(7):748-51. DOI: 10.1176/appi.ajp.2010.09091379. View

18.

Burt S, Klump K . The Michigan State University Twin Registry (MSUTR): an update. Twin Res Hum Genet. 2012; 16(1):344-50. PMC: 5800311. DOI: 10.1017/thg.2012.87. View

19.

Bralten J, Franke B, Waldman I, Rommelse N, Hartman C, Asherson P . Candidate genetic pathways for attention-deficit/hyperactivity disorder (ADHD) show association to hyperactive/impulsive symptoms in children with ADHD. J Am Acad Child Adolesc Psychiatry. 2013; 52(11):1204-1212.e1. DOI: 10.1016/j.jaac.2013.08.020. View

20.

Klump K, McGue M, Iacono W . Age differences in genetic and environmental influences on eating attitudes and behaviors in preadolescent and adolescent female twins. J Abnorm Psychol. 2000; 109(2):239-51. View