What if It Was Easier to Prevent Schizophrenia Than to Treat It?

Overview

Journal NPJ Schizophr

Date 2017 Jun 1

PMID 28560255

Authors

Kristen J Brennand

Affiliations

Soon will be listed here.

References

Israel M, Yuan S, Bardy C, Reyna S, Mu Y, Herrera C . Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. Nature. 2012; 482(7384):216-20. PMC: 3338985. DOI: 10.1038/nature10821. View

Robicsek O, Karry R, Petit I, Salman-Kesner N, Muller F, Klein E . Abnormal neuronal differentiation and mitochondrial dysfunction in hair follicle-derived induced pluripotent stem cells of schizophrenia patients. Mol Psychiatry. 2013; 18(10):1067-76. DOI: 10.1038/mp.2013.67. View

Hashimoto-Torii K, Torii M, Fujimoto M, Nakai A, El Fatimy R, Mezger V . Roles of heat shock factor 1 in neuronal response to fetal environmental risks and its relevance to brain disorders. Neuron. 2014; 82(3):560-72. PMC: 4051437. DOI: 10.1016/j.neuron.2014.03.002. View

Roussos P, Guennewig B, Kaczorowski D, Barry G, Brennand K . Activity-Dependent Changes in Gene Expression in Schizophrenia Human-Induced Pluripotent Stem Cell Neurons. JAMA Psychiatry. 2016; 73(11):1180-1188. PMC: 5437975. DOI: 10.1001/jamapsychiatry.2016.2575. View

Nguyen H, Byers B, Cord B, Shcheglovitov A, Byrne J, Gujar P . LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress. Cell Stem Cell. 2011; 8(3):267-80. PMC: 3578553. DOI: 10.1016/j.stem.2011.01.013. View

Brennand K, Savas J, Kim Y, Tran N, Simone A, Hashimoto-Torii K . Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia. Mol Psychiatry. 2014; 20(3):361-8. PMC: 4182344. DOI: 10.1038/mp.2014.22. View

Kondo T, Asai M, Tsukita K, Kutoku Y, Ohsawa Y, Sunada Y . Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness. Cell Stem Cell. 2013; 12(4):487-96. DOI: 10.1016/j.stem.2013.01.009. View

Topol A, Zhu S, Hartley B, English J, Hauberg M, Tran N . Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells. Cell Rep. 2016; 15(5):1024-1036. PMC: 4856588. DOI: 10.1016/j.celrep.2016.03.090. View

Molloy A, Brody L, Mills J, Scott J, Kirke P . The search for genetic polymorphisms in the homocysteine/folate pathway that contribute to the etiology of human neural tube defects. Birth Defects Res A Clin Mol Teratol. 2009; 85(4):285-94. PMC: 6129971. DOI: 10.1002/bdra.20566. View

10.

Mertens J, Marchetto M, Bardy C, Gage F . Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience. Nat Rev Neurosci. 2016; 17(7):424-37. PMC: 6276815. DOI: 10.1038/nrn.2016.46. View

11.

Chung C, Khurana V, Auluck P, Tardiff D, Mazzulli J, Soldner F . Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons. Science. 2013; 342(6161):983-7. PMC: 4022187. DOI: 10.1126/science.1245296. View

12.

Hauberg M, Roussos P, Grove J, Borglum A, Mattheisen M . Analyzing the Role of MicroRNAs in Schizophrenia in the Context of Common Genetic Risk Variants. JAMA Psychiatry. 2016; 73(4):369-77. PMC: 7005318. DOI: 10.1001/jamapsychiatry.2015.3018. View

13.

Byers B, Cord B, Nguyen H, Schule B, Fenno L, Lee P . SNCA triplication Parkinson's patient's iPSC-derived DA neurons accumulate α-synuclein and are susceptible to oxidative stress. PLoS One. 2011; 6(11):e26159. PMC: 3217921. DOI: 10.1371/journal.pone.0026159. View

14.

Sareen D, ORourke J, Meera P, Muhammad A, Grant S, Simpkinson M . Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion. Sci Transl Med. 2013; 5(208):208ra149. PMC: 4090945. DOI: 10.1126/scitranslmed.3007529. View

15.

Brennand K, Simone A, Jou J, Gelboin-Burkhart C, Tran N, Sangar S . Modelling schizophrenia using human induced pluripotent stem cells. Nature. 2011; 473(7346):221-5. PMC: 3392969. DOI: 10.1038/nature09915. View

16.

Yu D, Di Giorgio F, Yao J, Marchetto M, Brennand K, Wright R . Modeling hippocampal neurogenesis using human pluripotent stem cells. Stem Cell Reports. 2014; 2(3):295-310. PMC: 3964286. DOI: 10.1016/j.stemcr.2014.01.009. View

17.

Yoon K, Nguyen H, Ursini G, Zhang F, Kim N, Wen Z . Modeling a genetic risk for schizophrenia in iPSCs and mice reveals neural stem cell deficits associated with adherens junctions and polarity. Cell Stem Cell. 2014; 15(1):79-91. PMC: 4237009. DOI: 10.1016/j.stem.2014.05.003. View

18.

Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K . Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007; 131(5):861-72. DOI: 10.1016/j.cell.2007.11.019. View

19.

Wen Z, Nguyen H, Guo Z, Lalli M, Wang X, Su Y . Synaptic dysregulation in a human iPS cell model of mental disorders. Nature. 2014; 515(7527):414-8. PMC: 4501856. DOI: 10.1038/nature13716. View

20.

da Silveira Paulsen B, de Moraes Maciel R, Galina A, da Silveira M, Souza C, Drummond H . Altered oxygen metabolism associated to neurogenesis of induced pluripotent stem cells derived from a schizophrenic patient. Cell Transplant. 2011; 21(7):1547-59. DOI: 10.3727/096368911X600957. View